Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

A biopsy probe mechanism includes an elongate sample receiving member having a longitudinal axis and a sample receiving notch. A cutting cannula is arranged coaxially with the elongate sample receiving member. The elongate sample receiving member and the cutting cannula are movable relative to one another along the longitudinal axis between a first relative position and a second relative position. A plurality of echogenic features include a first echogenic feature established on the elongate sample receiving member and a second echogenic feature established on the cutting cannula. The first echogenic feature is in longitudinal alignment with the second echogenic feature when the elongate sample receiving member and the cutting cannula are in the first relative position. The first echogenic feature is out of longitudinal alignment with the second echogenic feature when the elongate sample receiving member and the cutting cannula are in the second relative position.

The present disclosure provides imaging agents that are useful for the detection and evaluation of heart conditions, such as myocardial infarction. Upon activation, the imaging agents of the present disclosure may be detected using an ultrasound imaging device.

Provided are a CEUS imaging method, an ultrasound imaging apparatus and a storage medium. The method includes: controlling an ultrasonic probe to transmit an ultrasonic wave to a target tissue containing a contrast agent, receive an echo of the ultrasonic wave, and acquire a first contrast data and a first tissue data in real time based on the echo of the ultrasonic wave, the first contrast data and the first tissue data being volumetric data; rendering a second contrast data and a second tissue data in real time to acquire a hybrid rendered image of the second contrast data and the second tissue data, the second contrast data containing all or part data of the first contrast data, and the second tissue data containing all or part data of the first tissue data; and displaying the hybrid rendered image in real time. The CEUS imaging method and the ultrasound imaging apparatus according to embodiments of the present disclosure help users more intuitively understand and observe the real-time spatial position relationship of a contrast agent in tissues, and further acquire more clinical information.

A system for tracking an instrument with ultrasound includes a probe (122) for transmitting and receiving ultrasonic energy and a transducer (130) associated with the probe and configured to move with the probe during use. A medical instrument (102) includes a sensor (120) configured to respond to the ultrasonic energy received from the probe. A control module (124) is stored in memory and configured to interpret the ultrasonic energy received from the probe and the sensor to determine a three dimensional location of the medical instrument and to inject a signal to the probe from the transducer to highlight a position of the sensor in an image.

Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

The ultrasonic diagnostic apparatus according to the present embodiment includes a frequency characteristic analysis circuit, a filter setting circuit, and a filter processing circuit. The frequency characteristic analysis circuit performs a frequency analysis on a first reception signal corresponding to a region of interest of each depth, and acquires a frequency characteristic of each depth. The filter setting circuit sets a reception filter of each depth based on the acquired frequency characteristic of each depth such that the acquired frequency characteristic of each depth shows a predetermined frequency characteristic. The filter processing circuit applies the set reception filter of each depth to a second reception signal corresponding to the region of interest of each depth, the second reception signal being after the first reception signal, and converts the second reception signal into a third reception signal corresponding to the region of interest of each depth.

The present invention discloses access devices and methods to create an access channel for introduction of one or more working devices into an anatomical region. The access channel is created using a visualization modality that is later removed before inserting one or more working devices through the access channel. This allows the methods and devices of the present invention to be used even in small sized natural or surgically created insertion tracts leading to the anatomical region. The access channel can be made of a device such as a sheath, a guidewire, and an elongate device comprising a lumen. Examples of visualization modalities are endoscopes and body insertable ultrasound imaging devices. The working devices can be used to perform a variety of diagnostic, therapeutic, or preventive procedures. Endometrial ablation devices and procedures have been used as an example to describe various aspects of the present invention.

Cancer treatment methods using thermotherapy and/or enhanced immunotherapy are disclosed herein. In one embodiment, the method comprising the steps of: (i) applying controlled thermal energy at 40-43° C. for a first predetermined time period to damage and weaken tumor cells of a tumor in a patient; (ii) administering pulsed high intensity focused ultrasound (pHIFU) in a first ultrasound mode to the tumor cells in the patient so as to damage the tumor cells without increasing the thermal energy; and (iii) administering low intensity focused ultrasound (LIFU) in a second ultrasound mode to further damage the tumor cells at a temperature of 39-43° C. for a second predetermined time period while performing observation of the tumor cells by ultrasonic thermometry.

Systems and methods for generating adaptive contrast accumulation imaging images are disclosed. A point spread function thinning/skeletonization technique may be performed on contrast enhanced image frames. An aggressiveness parameter of the technique may be adapted temporally and/or spatially. The aggressiveness parameter may be adapted based on various factors, including, but not limited to, time since injection of the contrast agent, signal intensity, and/or vessel size. The images may be temporally accumulated to generate a final sequence of adaptive contrast accumulation imaging images.