The present disclosure provides novel modified nanodroplets with a layerby-layer (LBL) assembly formulation (“LBLnNDs”). The LBLnNDs of the present disclosure comprise gaseous perfluorocarbon core, polymer shell, and multiple alternating positively and negatively charged biopolymer layers dispersed layerby-layer onto the shell of the LBLnNDs. Methods of making and use of the LBLnNDs are also provided.

A method for performing a medical procedure requiring effective, reliable and foolproof delivery of controlled amounts of a medical grade gas to a patient includes providing a compressed gas cylinder having a weight with medical grade gas sealed therein of at least twelve grams and not greater than fifty grams. The method also includes connecting the compressed gas cylinder to an integrated compressed gas unit including a regulator valve assembly positioned between an outlet port and an inlet port, wherein the regulator valve assembly includes a press button actuator and regulator adjustment dial. A flow control system is secured to the compressed gas unit and the medical grade gas is delivered in precisely controlled amounts by actuating the compressed gas unit and operating the flow control system to deliver the medical grade gas to vasculature of the patient.

A handle apparatus comprising detachable hardware and void regions or attachment devices that accommodate the shape of surgical devices and imaging units such that the device is held securely and mechanically fixed to the imaging unit within the handle assembly.

A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier. Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information.

Methods for contrast-enhanced ultrasound imaging that implement coded multi-pulses in each of two or more different transmission events are described. Data acquired in response to the two different transmission events are decoded and combined. In some embodiments, the coded multi-pulses include two or more consecutive Hadamard encoded ultrasound pulses. In other embodiments, multiplane wave pulses can be used. Such multiplane wave pulses can be coded using Hadamard encoding, as one example. In addition, the multiplane wave pulses can be further coded using amplitude modulation, pulse inversion, or pulse inversion amplitude modulation techniques.

The present invention relates to: a method for providing information for choosing a breast cancer treatment method by using a breast cancer ultrasonic image and gene information; a system for choosing a breast cancer treatment method by using a breast cancer ultrasonic image; and a method for providing information required for predicting the prognosis of a breast cancer patient.

This disclosure pertains to pharmaceutical compositions of aerosolized compositions containing mitochondria, methods of preparing and using the compositions, and devices for administering the compositions.

Systems and methods for time-varying two-dimensional (2D) color maps for visualizing images or sequences of images are disclosed. The 2D color map may include brightness values of a hue corresponding to different intensities that changes over time. In some 2D color maps, the hue used for the intensity scale may change over time while the brightness of a pixel may not. In some 2D color maps, both the hue and the brightness may change relative to intensity over time.

For tissue property estimation with ultrasound, multiple different types of measurements are performed by an ultrasound system, including scatter measurements and shear wave propagation measurements. The tissue property, such as liver fat fraction, is estimated using a combination of these different types of measurements.

The disclosure provides for a method for generating an ultrasound image that includes transmitting, by a plurality of transmitters in a transducer, at least two transmit beams at different angles, where at least parts of the transmit beams cover an overlapping region, and receiving, by a plurality of sensors of the transducer, reflected signals of the transmit beams. The method further comprises calculating channel coherence for the received signals to produce one or more channel coherence images, and calculating transmit coherence for the received signals to produce one or more transmit coherence images. The information from at least one of the channel coherence images and at least one of the transmit coherence images are combined to identify moving objects. The received signals from different transmits in overlapping regions are then processed to produce a final image that is compensated for the moving objects.