Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biontarkers associated with condition or disorder.

A system for collecting and utilizing health data can include collecting data relative to a patient's health and aggregating the data with other sources of data to define a database. The patient data can be collected using an electronic device, such as a smart contact lens or smart contact lens container. The data within the database can be manipulated, organized, or otherwise processed to determine trends, relationships, and other characteristics of the database. The characteristics of the database can be correlated to predict a health condition of the patient, generate a healthcare recommendation, or a combination thereof.

Determination system including a computing device (i) obtaining information related to an eye of a target person from a plurality of data sources and (ii) making a determination of a predetermined matter related to the target person based on at least part of the information. The plurality of data sources include two or more of a sensor included in a contact lens of the target person, a sensor included in a storage container of the contact lens, a measurement device which carries out measurement related to the eye of the target person, tear fluid of the target person, a storage solution of the contact lens and, a diagnostic process of the target person.

The objective of the present invention is to provide a liquid sample collector capable of collecting a trace amount of a specimen such as a tear safely and in an adequate amount. This trace amount liquid sample collector is characterized in that: the liquid sample collector is provided with a main body and a first absorbent body; the main body has at least one open end portion; the main body includes a hydrophobic material having elasticity; the first absorbent body is disposed at least partially inside the main body; the first absorbent body includes a water-absorbent material; and the first absorbent body is disposed in such a way as to be capable of coming into contact with the outside by way of the at least one open end portion of the main body.

Devices and methods for microbiome sampling and evaluation are disclosed. Devices including a capture substrate having first and second regions suitable for first and second analytic methods, respectively, are disclosed. Methods for collecting the microbiome sample with such devices are disclosed. Methods of evaluating the microbiome sample collected with such devices are disclosed. Kits including the devices for sampling and evaluating microbiome samples are also disclosed.

A blood glucose measurement apparatus includes: a control unit configured to determine a user's blood glucose level based on a concentration of body fluid secreted from the user; and a biometric information acquisition unit configured to acquire biometric information indicating a status of a user's autonomic nervous system. The control unit is configured to correct the determined blood glucose level based on the biometric information.

A tear glucose measuring device includes a tear glucose test strip (101) and a reaction device, wherein the tear glucose test strip (101) is used for collecting tears which are then subjected to an elution reaction with a glucose assay reagent contained in the reaction device. With this device, a user can collect tears by himself by folding a leading portion (1014) of the tear glucose test strip (101) about a folding line (1021) and inserting the leading portion (1014) into the lower conjunctival sac inside the lower eyelid to allow the absorbance of tears therein. If tear glucose test strips (101) of the same lot are consistent in terms of thickness of a moisture-absorbent layer of the leading portion (1014), as long as a tear collection region (1020) of the leading portion (1014) has a fixed area, the leading portion (1014) can collect a quantitative amount of tears. As such, tears can be sampled without needing to stimulate the lacrimal gland, and glucose in the collected tears will not be diluted and thus reflect the patient's true tear glucose level.

A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.

The present disclosure is directed toward methods for obtaining and processing ocular fluid samples from a subject in preparation for further analysis for diagnostic purposes. Ocular fluid provides a superior sample medium for biomarker analysis as compared to other biological media such as blood, serum, saliva, urine or bodily secretions. Proper sample collection and processing is critical for further use as a diagnostic medium as studies have shown that biomarkers found in ocular fluid can degrade quickly if mishandled.