The subject invention is related to the HVS and Pap smear testing apparatus providing Pap smear testing for Human Papilloma Virus (HPV) and HSV test for culture and sensitivity by doctor and patient automatically and being characterized by outer cylinder (1), head (2), interior side (3), end side (4), ring 1 (5), spiral end (6), ring 2a (7), internal cylinder 1 (8), piston cover (9), cylinder (10), protective cover (11), end part (12), outer end side (13), interior end side (14), flexible tube (15), medical tube (16), spring 1 (17), recoil cylinder 1 (18), line 1 (19.a), line 2 (19.b), ring 3 (20), ring 2b (21), spring 2 (22), internal cylinder 2 (23), ring 4 (24), hole 1 (25), tip holder (26), spring 3 (27), recoil cylinder 2 (28), hole 2 (29), circle 1 (30), coil (31), ring 5 (32), ring 6 (33), head bar 1 (34), cotton (35), empty space (36), accuracy sign (37), cone (38), circle 2 (39), black rubber (40), rear part (41), small cylinder 1 (42), wing (43), small cone (44), small cylinder 2 (45), head bar 2 (46), brush (47), ring 7 (48), brush bristle (49), sharp edge (50), and hole 3 (51).

Methods are disclosed for non-invasively obtaining fetal cells from a pregnant female. The methods include placing an absorbent medium in an interlabial or intravaginal space or adjacent to the perineum at the vaginal opening of the pregnant female, and collecting vaginal fluid comprising cells in the absorbent medium while the absorbent medium is interlabial or intravaginal space or adjacent to the perineum at the vaginal opening. The absorbent medium is removed and cells are isolated from the absorbent medium to obtain the fetal cells. The fetal cells can be, for example, somatic cells, embroyic stem cells, fetal stem cells or trophoblast cells.

A self-sampling device (1) for vaginal fluid from a vagina of a user, said self-sampling device (1) comprising an elongate first body (2) for insertion into the vagina of the user, and a sample collection body (3) for collecting a vaginal fluid sample from the user. The sample collection body (3) is attachable to an inner end portion (4) of the elongate first body (2) by a releasable connection means (5) comprising a shaft, a hole or recess for receiving the shaft, and a snap-locking means. The self-sampling device is used to take a vaginal fluid sample intended for subsequent laboratory analysis, for example, but not limited to, DNA analysis for HPV.

A container for collecting a biological specimen is provided that includes a peripheral wall extending from a base. The container further includes a longitudinal tower disposed within the container. The tower forms a partition within the container to form at least a first chamber and a second chamber therein, wherein the first and second chambers are in fluid communication with one another. In addition, the container includes an insert disposed within the container opposite the base, the insert comprising at least a first opening and a second opening. The second opening provides access to the second chamber and is further configured to engage a specimen collecting device to leave a portion of the specimen collecting device within the second chamber. The first opening provides access to the first chamber and is further configured to receive a syringe therein for accessing the biological specimen. Associated systems and methods are also provided.

The invention provides devices and methods for self-administered noninvasive retrieval of biological materials of the uterus and/or cervix and preimplantation stage embryos. The cervical device comprises a receptacle with a variable volume receptacle cavity, a controller configured to change the volume of the receptacle cavity, a surface for collection of biological materials, and a flexible pouch for generation of suction to facilitate efficient retrieval of biological materials. The biological materials retrieved include various biomarkers of diseases and disorders of reproduction, are directly isolated from a site of pathology, and are not metabolized or diluted. Information generated by analyzing these biological materials permits early diagnosis and prognosis assessments of disease and disorders of the female reproductive organs, irregularities of pregnancy, anomalies of the fetus in utero, and microbial infections.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

A massage device for massaging by means of pressure waves includes a housing having a handle segment and a massage segment and at least one chamber comprising an opening leading outward in the massage segment. The chamber includes an end wall segment, a first circumferential wall segment, and a second circumferential wall segment, the first circumferential wall segment being disposed between the end wall segment and the second circumferential wall segment, and the second circumferential wall segment defining the opening with the end wall segment being at least partially displaceable. The massage device further includes a drive device for inducing a predetermined vibration in the end wall segment, with the first circumferential wall segment being substantially rigid and the second circumferential wall segment being substantially flexible.

Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.

An appliance for vaginal penetration includes a grip, the appliance being designed to receive a working tool, especially an insemination gun that passes through the grip. A guiding tube extends the grip in order to form a compact assembly, the guiding tube being designed so as to receive the front tip of the working tool therein and receiving a video viewing device such as an endoscopy-type tube including a lighting element on the front end thereof, the appliance for vaginal penetration including an electronic cell receiving the video images, provided with a device for transmitting images to a remote screen.

A method of determining risk of preterm labor in an asymptomatic pregnant woman can include: obtaining a vaginal fluid sample from an asymptomatic pregnant woman; contacting the vaginal fluid sample with a PAMG-1 antibody that binds with PAMG-1; detecting whether the PAMG-1 antibody binds with PAMG-1 in the vaginal fluid sample to form a PAMG-1-antibody complex; and providing the determined risk to the pregnant woman. When the PAMG-1-antibody complex forms, the asymptomatic pregnant woman is determined to be susceptible to preterm labor because PAMG-1 is detected in the vaginal sample. When the PAMG-1-antibody complex does not form, the asymptomatic pregnant woman is determined to be not susceptible to preterm labor because the PAMG-1 is not detected in the vaginal sample.