An adapter manifold having an adapter body and a syringe applicator, wherein the adapter body has substantially parallel inlet ports and substantially parallel exit ports, the inlet ports spaced an axial distance apart which is different from an axial distance between the exit ports, to accommodate the syringe applicator which has multiple substantially parallel syringes, and substantially parallel syringe connectors in fluid communication with the inlet ports having Luer-type receivers on proximal ends thereof, wherein the syringe connectors are biased toward a proximal end of the adapter body.

Surgical methods involving cutting and sealing tissue include affixing a first adjunct material to tissue at a treatment site, such as by stapling the adjunct to tissue. A second adjunct material is applied to at least a portion of the first adjunct material such that the second adjunct material interacts with the first adjunct material to form a seal in an area of the tissue covered by at least one of the first and the second adjunct material. The resulting tissue sealing structure, which includes a combination of the two adjuncts, is believed to be superior to the sealing properties of either adjunct alone.

Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.

The present disclosure features a composition (e.g., adhesive composition), as well as devices and related means for packaging and delivery of the same. The devices and related methods may be used for activating and mixing the components of composition (e.g., adhesive composition), for example, within a packaged device without compromising sterility.

An adhesive-applicator, and an implant that includes a wall formed from a porous fabric, are transcatheterally advanced to a heart of a subject. While a nozzle of the adhesive-applicator is disposed within an interior of the implant, the external surface of the wall is adhered to tissue of the heart by using the adhesive-applicator to apply an adhesive via the nozzle to the interior, such that a portion of the adhesive passes through the porous fabric of the wall to the external surface. Other embodiments are also described.

A sealant syringe assembly includes a first syringe including a plurality of chambers and discharging a first solution which is a mixture of a buffer solution and compound powder; a reaction solution syringe including at least one chamber and discharging a reaction solution capable of reacting with the first solution; and a connector for connecting the first syringe and the reaction solution syringe to mix and discharge the first solution and the reaction solution. The first syringe includes three packing members provided inside the first syringe; a passage provided in the inner circumferential surface of the first syringe; and a plunger for providing a pressure to one of the packing members.

The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

The invention relates to a device and method for blocking air contributing to pneumothorax during a lung biopsy.

A sealant delivery device includes a housing, a matrix container connected with a distal end of the housing and being moveable between closed and opened positions, and a matrix, such as a hemostatic substrate, disposed within the matrix container. The sealant delivery device includes a sealant dispensing system in fluid communication with the matrix container that is configured for dispensing a sealant onto the matrix disposed within the matrix container. An actuator is coupled with the sealant dispensing system and the matrix container. The actuator is engageable for opening the matrix container for exposing the matrix and expressing the sealant onto the matrix. A component of the matrix container may be used to press the matrix and sealant expressed onto the matrix against target tissue to control bleeding of the target tissue.

Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.