The present disclosure describes, among other things, a thermo-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

An applicator (1) comprising: a body (2) defining a chamber (14) for storing an adhesive composition, and an outlet (16) for delivering the adhesive composition stored in the chamber (14), a piston (4) mobile in translation relative to the body (2), a drive element (6) mobile in rotation relative to the body (2), and configured to be releasably engaged with a guide (100, 200, 300) external to the applicator (1), wherein rotating the drive element (6) relative to the body (2) causes the piston (4) to translate relative to the body (2) so as to reduce a volume of the chamber (14) and force the adhesive composition out of the applicator (1) through the outlet (16).

A bone fixation system, device and method are provided herein. A system may include a bone plate. The bone plate is adapted to be affixed to a bone surface, and comprises a bioactive porous portion. The porous portion is adapted to, include bone healing-promoting substances, such as hollow microparticles containing the bone healing-promoting substances embedded in the porous portion. The bone plate father includes at least one attachment portion. In some embodiments, the attachment portion includes a face, which defines indentations, such as dimples, to retain an amount of adhesive.

Surgical methods involving cutting and sealing tissue include affixing a first adjunct material to tissue at a treatment site, such as by stapling the adjunct to tissue. A second adjunct material is applied to at least a portion of the first adjunct material such that the second adjunct material interacts with the first adjunct material to form a seal in an area of the tissue covered by at least one of the first and the second adjunct material. The resulting tissue sealing structure, which includes a combination of the two adjuncts, is believed to be superior to the sealing properties of either adjunct alone.

Devices, systems and methods for applying a bioadhesive substance to an internal surface of the eye, such as the retina, can include an outer sleeve having a proximal end, a distal end, a passageway extending along a length of the elongate body and an opening at the distal end of the elongate body, an applicator tip including an elongate body having a proximal end and a distal end, an applicator portion coupled with the distal end of the elongate body, and a substance supply lumen extending along a length of the device through which a bioadhesive substance can pass so that the bioadhesive substance can be applied to at least the applicator portion of the applicator tip. Some embodiments of the device can also have a source of the bioadhesive substance in fluid communication with at least the substance supply lumen.

Devices and methods for placing an adjunct at a tissue treatment site prior to delivering staples through the tissue and adjunct are provided. In one embodiment, a flowable adjunct precursor can be deposited on the surface of the tissue at the tissue treatment site. The flowable adjunct precursor can be configured to solidify after deposition to form an adjunct. In another embodiment, an adjunct delivery device can include a non-stapling end effector configured to deliver an adjunct to a tissue treatment site. In either case, staples can be delivered through the adjunct and tissue after placement of the adjunct at the tissue treatment site.

Methods and apparatus for treating veins are disclosed. In one example, a method for treating a vein includes: positioning a distal end of a delivery tool, such as a syringe and needle or catheter, within the vein; introducing media from the delivery tool into the vein; and creating an occlusion in the vein by exposing the media to energy using an artificial energy source.

A system is configured to bring about anastomosis between two lumens in a patient or between two sections of a single lumen in a patient. The anastomosis system includes a first tissue-compressing element, a second tissue-compressing element, and an energy source. The energy source can be a thermal energy source or laser energy source. Tissue is interposed between the elements. Magnetic material incorporated into the tissue-compressing elements facilitates the alignment of the elements as well as compression of the interposed tissue. The energy source can deliver energy to tissue. This delivery of energy can cause local changes to the tissue that can help maintain positional stability of the implants, can bring about immediate patency of the anastomosis and can otherwise facilitate achieving desired outcomes for the patient.

Electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.

A device for occluding a perforation in a blood vessel includes an expandable member. The expandable member includes a central expandable balloon disposed between a proximal and a distal balloon, wherein the proximal and distal balloons each contain first and second compositions, respectively. The proximal, central and distal balloons have respective stiffnesses, and the central balloon has a third stiffness that is less than the first and second stiffnesses. Upon expansion, the central balloon causes the proximal balloon and the distal balloon to substantially simultaneously release the first and second compositions, thereby allowing the first composition and the second composition to combine in-situ and form, therein, a biocompatible foam to occlude a perforation within the vasculature.