The disclosed technology provides an implantable device for sealing an aperture in a tissue of a body lumen. In some embodiments, the implantable device comprises a flexible sealable member having an elongated shape so that a longitudinal dimension of the flexible sealable member is greater than a lateral dimension of the flexible sealable member.

In various aspects, present disclosure is directed to methods, devices and systems whereby one or more low viscosity fluids may be introduced into a catheter and whereby the one or more low viscosity fluids may be converted into a high viscosity fluid in the catheter, which high viscosity fluid may be delivered from an exit port of the catheter.

Described herein are systems, devices, and methods for closing a perforation in any hollow vessel associated with a mammalian surgical procedure, for example a device for sealing an aperture in a tissue, the device comprising an implant and a delivery shaft configured to engage the implant, the delivery shaft comprising (i) a retaining sleeve, (ii) a release sleeve, and (iii) a handle coupled to the delivery shaft.

Valvular implants and blood vessel closure devices herein are configured to be positioned in the heart and to block regurgitant blood flow from the heart into blood vessels supplying blood to the heart. The valvular implants can have a cover, a membrane, a valve, a resilient frame, and/or other features. Some valvular implants can have anchors to be positioned in the blood vessels, such as in pulmonary veins, and can anchor the implant to the heart wall. Various embodiments of covers and/or membranes act as valves contracting and expanding, to alternately permit and block blood flow. The valvular implants can cover one or more blood vessels, such as one, two, three, or four pulmonary veins, and can also be configured and implanted to block an appendage to the heart, such as the left atrial appendage.

An in-tube transit object that is inserted in a tube includes: a coil section formed by winding a wire; and a fiber section attached to an end on one side and an end on the other side in a winding-axis direction of the coil section. The coil section is formed with a large diameter section, through which fiber of the fiber section is inserted, at the end on the one side and the end on the other side, and is inserted in an extending state in the winding-axis direction when the in-tube transit object is inserted into the tube. The fiber section is configured to expand when seen in the winding-axis direction in the case where the in-tube transit object is inserted in the tube and then discharged from the tube, which brings the coil section into a compressed state in the winding-axis direction.

In some embodiments, an apparatus includes an introducer sheath and a dilator. The introducer sheath can include a body portion and a tip portion. The body portion can be coupled to the tip portion via a seal portion. The dilator can be configured to be inserted into a lumen defined by the introducer sheath such that the dilator can engage with the tip portion and translate the tip portion relative to the body portion such that the tip portion moves the seal portion from a biased neutral configuration to an extended configuration for delivery of the apparatus to a location in a patient's body. The seal portion can have a larger outermost diameter in the neutral configuration than in the extended configuration.

A treatment system includes an insert that is resiliently deflectable. The tip portion of the insert can be configured to be coupled to the trailing portion of an implant. A guide tube having an internal lumen is configured to permit passage of the tip portion and the body portion of the insert through a guide tube. The guide tube can have a length that is less than that of the insert. Treatment systems include a plurality of inserts, each insert differing from in at least one of length, diameter, and curvature. Treating a patient can include sizing a fistula using an insert.

A vascular closure system is configured to seal an incision in a vessel of the patient's body. The system includes a slider that is moved from an initial position to a deployed position (that is, towards the puncture of the patient body), until the proximal end of the slider exposes a reference marker on an inner tube. This confirms the deployment of the closure element and completely expands or opens or pivots the closure element in the blood vessel.

A method of manufacturing a reduced-pressure abdominal treatment system for treating an open abdominal cavity is provided. In some embodiments, the reduced-pressure abdominal treatment system has an open-cavity treatment device for providing reduced-pressure treatment to an abdominal cavity; a deep-tissue closure device for applying a closing force on a deep-tissue wound; and a surface-wound closure subsystem for providing a closing force on a surface wound. The method of manufacturing may also include providing a reduced-pressure supply subsystem. A method of treatment using a reduced-pressure abdominal treatment system is also disclosed.

A puncture sealing system for sealing a vascular puncture comprises an inner member comprising an expandable member at an inner member distal end and an inflation lumen that extends from an inner member proximal end to an interior of the expandable member. The puncture sealing system also comprises an outer member comprising a lumen sized and shaped to allow the inner member to slide therein, an occlusion balloon at an outer member distal end, and an inflation lumen that extends from an outer member proximal end to the interior of the occlusion balloon. The expandable member can be inflated by fluid flowing through the inner member inflation lumen so that the expandable member can inflate in a subcutaneous vessel of a living being, and the occlusion balloon can be inflated by fluid flowing through the outer member inflation lumen so that the occlusion balloon can enable the occlusion of a vascular puncture and contact and apply pressure to a puncture tract extending from the vascular puncture. In one version, the inner member further comprises a vessel locator system. In one version, the puncture sealing system further comprises an obturator slidably receivable within the outer member and having a distal end adapted to at least partially cover the puncture.