A method for maintaining the alignment of the edges of a trocar defect by inserting into a defect a device for compressing the tissue such that part of the device is above while the other is below the defect, then pulling back on the device so that the part below the defect is up against the defect, then while holding the device below the defect in place, push down on the part above the wound so that it compresses the tissue. Finally, release the device from the insertion tool.

Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.

An occlusion device may comprise a first tube having a first balloon positioned at a distal end, and a second tube having a second balloon positioned at a distal end. The first balloon may be sized and configured to occlude a vascular lumen upstream of a vascular puncture, and the second balloon may be sized and configured to simultaneously occlude the vascular lumen downstream of the vascular puncture. A method of occluding a vascular puncture may comprise positioning a distal end of an occlusion device comprising a first balloon and a second balloon through the vascular puncture and into a vascular lumen. The first balloon may be positioned downstream of the vascular puncture, and the second balloon may be positioning upstream of the vascular puncture.

Systems and methods are provided for using an actuator to deploy an implant configured to close a tissue puncture or a natural opening in a body. The actuator includes a handle that is rotated in a first direction to deploy a first set of deployable wings of the implant, and that is rotated in a second, opposite direction to deploy a second set of deployable wings of the implant. A guide wire coupled between the implant and the actuator rotates and/or moves axially with the actuator to cause the wings to deploy. After each of the first and second rotation strokes, the handle is prevented from rotating beyond the first and second strokes, respectively. After the wings are deployed to engage tissue therebetween, the handle is operated to eject the implant from the actuator.

Valvular implants and blood vessel closure devices herein are configured to be positioned in the heart and to block regurgitant blood flow from the heart into blood vessels supplying blood to the heart. The valvular implants can have a cover, a membrane, a valve, a resilient frame, and/or other features. Some valvular implants can have anchors to be positioned in the blood vessels, such as in pulmonary veins, and can anchor the implant to the heart wall. Various embodiments of covers and/or membranes act as valves contracting and expanding, to alternately permit and block blood flow. The valvular implants can cover one or more blood vessels, such as one, two, three, or four pulmonary veins, and can also be configured and implanted to block an appendage to the heart, such as the left atrial appendage.

Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery. Embodiments of the systems and methods can be used in combination with embolic protection systems including blood flow reversal mechanisms, arterial filters, and arterial occlusion devices.

A modular, reduced-pressure, wound-closure system for providing a closing force on a surface would includes a flexible strap operable to be formed into a closed loop inbound and around the surface wound and a plurality of modular closing members coupled to the flexible strap. A reduced-pressure source is fluidly coupled to the plurality of modular closing members. The modular closing members are operable to generate a closing force on the surface wound. A portion of the modular closing members are releasably attached to the patient's epidermis proximate the surface wound and another portion are attached to the flexible strap. A reduced pressure from the reduced-pressure source is delivered to each modular closing member to generate the closing force on the surface wound. Methods and other systems are presented.

An occlusion device for occluding a left atrial appendage extending from a lateral wall of a left atrium of a heart including a first clamping portion and a second clamping portion movably connected to one another and configured for positioning along opposed sides of the left atrial appendage. The first clamping portion and the second clamping portion each may include an inner side configured to face toward the left atrial appendage when the device is in a deployed configuration, an outer side disposed opposite the inner side and configured to face away from the left atrial appendage when the device is in the deployed configuration. A pair of sleeves may be coupled to the outer side of each clamping portion. Each sleeve defines a channel configured to accept a medical tool to facilitate moving the device between an open and closed configuration.

Described herein are systems, devices, and methods for closing a perforation in any hollow vessel associated with a mammalian surgical procedure, for example a device for sealing an aperture in a tissue, the device comprising an implant and a delivery shaft configured to engage the implant, the delivery shaft comprising (i) a retaining sleeve, (ii) a release sleeve, and (iii) a handle coupled to the delivery shaft.

Valvular implants and blood vessel closure devices herein are configured to be positioned in the heart and to block regurgitant blood flow from the heart into blood vessels supplying blood to the heart. The device can include an expandable docking station configured to be installed in the left atrium of the heart, at least one valve retained in a docking portion of the docking station, and a fluid blocking material secured to the docking station and configured to surround the first and second pulmonary vein openings and provide a fluid seal around the at least one valve.