An apparatus is provided for sealing a blood vessel wall penetration disposed at an end of a tissue tract. The apparatus, in one embodiment, includes a shaft having a proximal end and a distal end; an occlusion element near the distal end of the shaft; a hemostatic implant disposed over or adjacent to an exterior surface of the shaft proximal to the occlusion element, said hemostatic implant being hydratable to expand to occlude the tissue tract when exposed to body fluids within the tissue tract; a sleeve peelably disposed over an outer surface of the hemostatic implant and proximal to the occlusion element; and wherein peeling of the sleeve exposes the hemostatic implant such that the hemostatic implant expands and occludes the tissue tract.

Closure systems, kits and methods for sealing a percutaneous puncture or other opening in a blood vessel wall, body cavity or biopsy tract are disclosed. A closure system can comprise an implant assembly, a delivery assembly, and an introducer sheath. The closure system can further comprise a valve bypass and a dilator. The implant assembly can include an inner member, a sealing membrane, and an outer member, each of which can be delivered by the delivery assembly. The inner member can be extended through the puncture or opening and positioned adjacent an inner tissue surface. The outer member can be positioned adjacent an outer tissue surface. The sealing membrane can have a distal end attached to the inner member, a proximal end including an opening configured to receive the outer member, and a mid-region therebetween. The outer member, when expanded from a delivery configuration to a sealing configuration, can urge the mid-region of the sealing membrane radially outward such that its outer surface can contact and conform to a perimeter edge of the puncture or opening.

The disclosed technology provides an implantable device for sealing an aperture in a tissue of a body lumen. In some embodiments, the implantable device comprises a flexible sealable member having an elongated shape so that a longitudinal dimension of the flexible sealable member is greater than a lateral dimension of the flexible sealable member.

Surgical assemblies are provided, including an introducer sheath defining a central lumen and a blood signal port, an actuator having an elongate shaft extending distally therefrom, and a deployable coupler coupled to a distal end of the elongate shaft. The actuator is configured to couple to the introducer sheath at the proximal end such that the elongate shaft extends through the central lumen of the introducer sheath. The deployable coupler has a plurality of proximal slits configured to form a proximal wing and a plurality of distal slits configured to form a distal wing, and is disposed distally of the introducer sheath when the actuator is coupled to the introducer sheath. A blood signal flow inlet is defined between the introducer sheath and the deployable coupler such that blood can enter the blood signal flow inlet, travel the central lumen, and exit via the blood signal port.

An occlusion device for occluding a left atrial appendage extending from a lateral wall of a left atrium of a heart including a first clamping portion and a second clamping portion movably connected to one another and configured for positioning along opposed sides of the left atrial appendage. The first clamping portion and the second clamping portion each may include an inner side configured to face toward the left atrial appendage when the device is in a deployed configuration, an outer side disposed opposite the inner side and configured to face away from the left atrial appendage when the device is in the deployed configuration. A pair of sleeves may be coupled to the outer side of each clamping portion. Each sleeve defines a channel configured to accept a medical tool to facilitate moving the device between an open and closed configuration.

Devices and methods for creating hemostasis at a subcutaneous vascular puncture are disclosed. The methods and devices may be used to close vascular punctures following trans-radial arterial procedures, e.g., catheterization and percutaneous coronary intervention. The devices may include a housing defining a suction chamber and an anvil disposed within the suction chamber and adhesively attached to the limb of a patient such that the apparatus creates a pulling force as well as a pushing force on the patient's skin, subcutaneous tissue, and artery. Alternatively, the pulling force and pushing force may be accomplished be mechanical means.