Devices and methods are described for occluding the left atrial appendage (LAA). The device excludes the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. The implantable device is delivered via transcatheter delivery into the LAA and secured within the LAA. The implant comprises an expandable and compliant frame and an expandable and conformable tubular foam body. The device may have a thromboresistant cover at a proximal end. The frame may have recapture struts inclining radially outwardly from a central hub. The frame may have axially extending side wall struts, with adjacent pairs of side wall struts joined at one or more apexes. Anchors extend from the frame and into the foam to engage tissue.

Described herein are devices and mechanisms for effective and streamlined ratcheting of handheld medical devices, for example, medical ratcheting screwdrivers. In some embodiments, a ratcheting mechanism is included, which comprises a moveable component, which can comprise a plurality of teeth, an engagement component comprising a plurality of protrusions configured to engage with the teeth, and a toggle collar between the moveable component and the engagement component. In some embodiments the toggle collar comprises stops configured to engage the protrusions and configured to toggle the ratcheting mechanism between modes allowing transmission of torque and force in a first rotational direction, but disallowing it in a second rotational direction and a mode allowing transmission of torque and force in the second rotational direction, but disallowing it in the first rotational direction.

A surgical apparatus includes an end effector having an ultrasonic blade, a clamp arm, and a clamp pad. The end effector applies ultrasonic energy at the blade. The clamp arm pivots relative to the blade. The clamp pad is positioned on the clamp arm adjacent to the blade. The clamp arm includes a latching feature to retain the clamp pad relative to the clamp arm to prevent the clamp pad from moving laterally, longitudinally, and perpendicularly relative to the clamp arm.

A package (10a) for containing a medical device (12a) including a front sheet (14a) and a back sheet (15a) wherein each includes a top edge (18a, 23a), a bottom edge (19a) and opposed first (20a, 24a) and second side edges (21a, 25a), the sheets being sealed to each other by a peelable peripheral seal (26a), having a top seal zone (27a), bottom seal zone (28a), and opposed first (29a) and second side seal zones (30a), the sheets being separated to open the package by at least partially peeling the sheets apart along the first and second side seal zones; a first peel-stop (31a) located in the first side seal zone and a second peel-stop (32a) located in the second side seal zone of the peripheral seal, wherein the first and second peel-stops limit peeling of the first and second side seal zones of the peripheral seal.

A liquid applicator (1) for holding and discharging a curable liquid composition, comprises a receiver body (2) for holding a curable liquid composition, a discharge tip (20;30;40) having a longitudinal axis and further having a distal end remote from the receiver body (2) from which the liquid composition is discharged, and a discharge mechanism (5) for transferring liquid composition held by the applicator (1) to the tip (20;30;40) for discharge of the composition. The tip (20;30;40) comprises an outlet section (21d;31d;44d) having at least one groove formation (26;38;48) extending along the tip (20;30;40) to the distal end thereof. The applicator may be a surgical adhesive applicator.

Devices and methods for treating a sinus venosus atrial septal defect. A treatment device may have a tubular shape and may be configured to be arranged to provide a conduit between an upper right pulmonary vein (PV) and a left atrium (LA). The device may have a proximal portion comprising a flexible mesh configured to anchor within the LA, a distal portion comprising a flexible mesh configured to anchor within the target PV, and a central portion having a plurality of elongate parallel bars. A method for treating a sinus venosus atrial septal defect may include percutaneously advancing the device through the femoral vein and inferior vena cava (IVC), and into the right atrium (RA). The method may include creating a trans-septal opening, passing the device through the opening into the LA, and toward the upper right PV to treat the defect.

A tool useful for deploying a flip anchor connected to a cable includes a housing with a first end and a second end; and a guiding tube having a bore therethrough. The guiding tube has a proximal end releasably connected to the first end of said housing, and a distal end configured to hold said flip anchor. The housing includes a mechanism having a low resistance surface and a slider having a high friction surface facing the low resistance surface, where the slider is movable between a) a clamping position configured to clamp the cable between the low resistance surface and the high friction surface; and b) a release position configured to allow the cable to move freely on the low resistance surface. A safety button on said housing is movable between an elevated position where the safety button holds the slider in said first position, and a depressed position where the safety button releases the slider, allowing it to enter the second position. The slider is configured to move the cable distally upon movement from the clamping position to the release position, deploying the flip anchor from the guiding tube.

A surface coating structure of a surgical prosthesis according to an exemplary embodiment of the present disclosure may include: a first coating layer formed on the surface of the surgical prosthesis and including an amino compound for surface adhesion; a second coating layer formed on one side of the first coating layer and including a fluorine compound conferring hydrophobicity to the surface coating structure of the surgical prosthesis; and a third coating layer formed on one side of the second coating layer and including a lubricant component for preventing adhesion of a biomaterial existing in a subject into which the surgical prosthesis is inserted.

Catheter based systems for isolated stenting of an intravascular lesion can include two expandable occlusion devices with a balloon expandable stent or self-expanding stent therebetween. Expandable occlusion devices can be expanded in a distal direction and a proximal direction in relation to the lesion to occlude vasculature. A treatment agent can be injected into a cavity formed between the expandable occlusion device. A coating can be applied to one or both occlusion devices to prevent adherence to the treatment agent. The stent can be deployed across the lesion while the occlusion devices are in place. Fragments dislodged during stenting can be aspirated.

Devices and methods are described for occluding the left atrial appendage (LAA). The device excludes the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. The implantable device is delivered via transcatheter delivery into the LAA and secured within the LAA. The implant comprises an expandable and compliant frame and an expandable and conformable tubular foam body carried by the frame. The device may have a thromboresistant cover at a proximal end and a thromboresistant coating on the foam body. The frame may have recapture struts inclining radially outwardly in the distal direction from a central hub. The frame may have axially extending side wall struts, with adjacent pairs of side wall struts joined at one or more apexes. Anchors extend from the frame to engage tissue. The anchors can also be reversible to allow retraction of the anchors and repositioning or retrieval of the device.