Exclusion devices for anatomical structures, and related instruments and related methods, are disclosed. An exclusion device for an anatomical structure may include a first beam, a second beam, and/or a first spring operatively coupled to the first beam and the second beam to exert a closing force on the first beam and the second beam. The first spring may be generally U-shaped and/or may include a first end portion and a second end portion generally opposite a connecting portion.

A surgical stapler, or fastening instrument, may generally comprise a layer, such as a tissue thickness compensator, for example, releasably attached to a fastener cartridge and/or anvil by a flowable attachment portion. The flowable attachment portion may be indefinitely flowable. The flowable attachment portion may be flowable from the time that layer is installed to the fastener cartridge to the time in which the layer is implanted to patient tissue. The flowable attachment portion may comprise a pressure sensitive adhesive. The flowable attachment portion may comprise an adhesive laminate comprising a base layer comprising the tissue thickness compensator and an adhesive layer on at least a portion of a surface of the base layer comprising the pressure sensitive adhesive. Articles of manufacture comprising flowable attachment portion and methods of making and using the flowable attachment portion are also described.

The present disclosure is directed to embodiments of an occlusive medical device including a frame and at least one closure coupled to the frame. The frame includes a distal annular flange having a radially outer surface and a radially inner surface, a proximal annular flange having a radially outer surface and a radially inner surface, and a waist portion extending between and connecting the distal annular flange to the proximal annular flange. The radially inner surface of the distal annular flange, the waist member, and the radially inner surface of the proximal annular flange define an unobstructed passageway through the frame. The at least one closure is configured to close the passageway to: (i) provide an occlusive effect, and (ii) enable subsequent access through the passageway.

A device for applying a tissue healing agent includes an insertion member extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, a delivery element including a first surface and a second surface opposing one another, the delivery element movable between a closed configuration, in which the delivery element is compressed to be received within the channel, and an open configuration, in which the delivery element is substantially planar, and a first tissue healing agent formed in a sheet configuration and disposed on the first surface of the delivery element.

A surgical stapling apparatus includes a buttress retention assembly. The buttress retention assembly includes a sleeve configured to be detachably coupled with a first jaw member of a tool assembly of the surgical stapling apparatus, and a buttress material. The sleeve includes a proximal hook extending transversely outward from a lateral side of the sleeve, and a mouth including a hook configured to be received in a knife slot of the first jaw member. The mouth includes an inner surface having an inwardly extending boss. The buttress material includes a tab extending transversely outward from a lateral side thereof. The tab defines a proximal slot configured to receive the proximal hook of the sleeve. At least a portion of the distal end portion extends through the mouth of the sleeve. The distal end portion defines a distal slot dimensioned to receive the boss of the sleeve.

Inflatable compression devices are disclosed. In some embodiments the devices provide compression to the torso of a patient, including at a pocket configured to receive a pacing device. In some embodiments at least one securing strap is displaceable with respect to a compression member. In some embodiments a compression member is displaceable relative to at least one securing strap.

The present invention provides fastener anchoring devices with protruding fasteners releasably attached to graspers for insertion into a target site such as soft tissue. The devices include a retaining mechanism that can be actuated to release the fasteners from the grasper. The devices can include support material preloaded onto the fasteners.

A surface-modified cannula includes a hollow shaft having a proximal opening and one or more surface features along a portion of the length of the hollow shaft, the one or more surface features including one or more channels, one or more depressions, and/or two or more ports each extending at least partially between an outer diameter and an inner diameter of the hollow shaft. The one or more surface features are configured to enable, upon delivery of the cannula to a position proximate to a wound site in the blood vessel, collection of the patient’s blood from the wound site, and ejection of the blood along an access path to the wound site, thereby enabling blood to migrate from the wound site to a region surrounding and extending from the wound site along the access path.

Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.

A tissue thickness compensator may generally comprise a compressible core comprising a plurality of movable particles, and a wrap surrounding the compressible core. The plurality of movable particles may comprise at least one medicament. A tissue thickness compensator may generally comprise a compressible core comprising a plurality of crushable particles, and a wrap surrounding the compressible core. The plurality of crushable particles may comprise at least one medicament. The compressible core may comprise a material selected from a group consisting of a biocompatible material. The wrap may comprise a material selected from a group consisting of a biocompatible material. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.