Abdominal closure method and device variations for closing ventral hernias and reducing recurrence are described. The tissue anchoring assembly may generally include a first prong defining a lumen at least partially therethrough. The first prong may further define one or more openings or channels at least partially along the first prong and an opening near or at a base of the first prong such that the one or more openings or channels and the opening are in communication via the lumen. A first member may extend from the base of the first prong for contact against a first tissue surface and a second member may be configured to move relative to the first prong for contact against a second tissue surface such that the first member and the second member are secured relative to one another.

Devices and methods of endolumenal formation of gastric sleeves are described. Some embodiments allow templating of a gastric sleeve by a gastric bougie, exposing a selected amount of tissue for suturing access, while maintaining sufficient internal working space for suturing within the template lumen.

Devices, systems and methods for fixating soft tissue to bone. In one embodiment, a repair device system for fixating soft tissue to bone includes a carrier member, multiple anchors, and a bone anchor. The carrier member includes multiple pad portions and a bone coupling portion. Each of the pad portions are aligned with an adjacent pad portion. The pad portions are configured to be positioned over a side of the soft tissue and the bone coupling portion is coupled to the multiple pad portions. Each anchor is sized and configured to extend through the at least one opening defined in one of the multiple pad portions and through the soft tissue. The bone anchor is configured to be coupled to the bone coupling portion and configured to be secured to the bone.

A method of stapling tissue is disclosed. The method can include obtaining a staple cartridge including a plurality of staples, wherein each staple has a base and a leg extending from the base. The stapling method can also include firing the staples from the staple cartridge, wherein the staples are fired into tissue in a staple line. The staple line can include a first portion having a first flexibility and a second portion having a second flexibility, wherein the second flexibility is different than the first flexibility. A method of stapling tissue can also include adapting an anvil with an anvil plate having an arrangement of staple-forming pockets that differs from the staple-forming pockets in the anvil.

Devices and methods for manipulating devices such as micro-scale devices are provided. The devices can include a tether of various materials surrounded by a stiff body. The tether interfaces with microscale devices to draw them against the stiff body, holding the microscale devices in a locked position for insertion into or extraction out of tissue. The tensional hook and stiff body are configurable in a multitude of positions and geometries to provide increased engagement. Such configurations allow for a range of implantation and extraction surgical procedures for the device within research and clinical settings.

Devices, systems and/or methods for repairing soft tissue adjacent a soft tissue repair site. In one embodiment, the repair device includes an anchor member having a base with at least four legs extending from the base. The base extends with a generally flat circular profile defining an upper surface and an underside surface with a central opening extending therethrough. Further, the at least four legs extend from the base with an elongated angled portion, the elongated angled portion being oriented at an angle less than seventy-five degrees relative to the underside surface of the base. With this arrangement, the anchor member may be fixated to soft tissue by rotating the base with a delivery tool so that the elongated angled portion of the at least four legs facilitates the anchor member sinking into the soft tissue and fixating thereto.

The present disclosure includes a plurality of securing devices. For example, the present disclosure includes securing devices comprising sutures, everting anchors, and inverting anchors. The sutures and anchors disclosed herein may be capable of deployment to a depth within a body lumen, such that body tissue external to the body lumen is not damaged by the devices. Moreover, in various embodiments, the securing devices described herein may couple one or more medical devices (e.g., stents, grafts, and/or stent-grafts) to body tissue such as a body lumen.

Devices, systems and/or methods for fixating soft tissue to bone are provided. In one embodiment, a repair device for fixating soft tissue to bone with a bone anchor includes a soft tissue anchor and one or more flexible members. The soft tissue anchor includes a base with multiple legs extending from the base. The one or more flexible members are coupled to the base and configured to extend from the base to the bone anchor with a fixed length. With this arrangement, the fixed length of the one or more flexible members is configured to maintain a fixed distance between the soft tissue anchor and the bone anchor such that, as the bone anchor is seated into bone, the one or more flexible members pulls the soft tissue anchor down against the soft tissue to fixate the soft tissue to the bone.

Devices and methods of endolumenal formation of gastric sleeves are described. Some embodiments allow templating of a gastric sleeve by a gastric bougie, exposing a selected amount of tissue for suturing access, while maintaining sufficient internal working space for suturing within the template lumen.

A system for treating cardiac dysfunction can include an expandable device for insertion into a heart, a foot configured to contact a portion of the heart, a support frame, and a membrane coupled to the support frame. The support frame can include a plurality of radially expandable struts each having a first free end configured to extend beyond the foot and a second end coupled to the foot. The plurality of radially expandable struts can include a plurality of staggered stops, and each of the stops can be positioned on a respective one of the struts proximal to the first free end of the respective one of the struts. Method for treating cardiac dysfunction can include implanting the systems described herein into a chamber of the heart.