A clipping system includes a clip having a pair of clip arms, proximal ends of the clip arms slidably received within a channel of a capsule to be moved between an open configuration and a closed configuration. A proximal end of the capsule including connecting tabs extending proximally therefrom. An applicator includes an elongated flexible member and a control member extending therethrough. The control member includes a distal end connected to the clip arms to move the clip assembly between the open and closed configurations. A distal end of the elongated flexible member includes a bushing including a first ramped surface, along which the connecting tabs slide along to engage a corresponding engaging feature of the bushing, and a second ramped surface proximal of the first ramped surface, the connecting tabs slidable along the second ramped surface to plastically deform toward a deployed configuration.

A clipping system includes a clip having a pair of clip arms, proximal ends of the clip arms slidably received within a channel of a capsule to be moved between an open configuration and a closed configuration. A proximal end of the capsule including connecting tabs extending proximally therefrom. An applicator includes an elongated flexible member and a control member extending therethrough. The control member includes a distal end connected to the clip arms to move the clip assembly between the open and closed configurations. A distal end of the elongated flexible member includes a bushing including a first ramped surface, along which the connecting tabs slide along to engage a corresponding engaging feature of the bushing, and a second ramped surface proximal of the first ramped surface, the connecting tabs slidable along the second ramped surface to plastically deform toward a deployed configuration.

Method and apparatus for delivering multiple tissue fasteners with needle and fastener assemblies each of which comprises a hollow needle adapted to be passed through tissue layers to be fastened, the needle containing a proximal and a distal implant, the implants being configured to self-expand when ejected from the needle, the implants being lockable to each other after ejection in response to drawing the implants together with tissue gripped between the implants.

Method and apparatus for delivering multiple tissue fasteners with needle and fastener assemblies each of which comprises a hollow needle adapted to be passed through tissue layers to be fastened, the needle containing a proximal and a distal implant, the implants being configured to self-expand when ejected from the needle, the implants being lockable to each other after ejection in response to drawing the implants together with tissue gripped between the implants.

Valve repair systems and clips for attachment to one or more leaflets of a heart valve. The clip can include an elongated member configured to be positioned between two leaflets of the heart valve. The elongated member can have a first portion and a second portion that extends from the first portion. A width of the second portion can be greater than the width of the first portion. A pair of arms can be coupled to the first portion and extend toward the second portion. The pair of arms can extend radially away from the elongated member as the pair of arms extend away from the first portion toward the second portion when the arms are in an open position. And the pair of arms can be moveable from the open position to a closed position to pinch each leaflet between one of the arms and the elongated member.

A device for treating tissue includes a clip including clip arms and a coupler. Each of the clip arms extends from a proximal end to a distal end. Proximal ends of the clip arms are slidably received within a channel of a capsule. A proximal end of the capsule includes openings extending through a wall. The coupler is mounted over the proximal end of the capsule via deployment arms including engaging features extending laterally inward from an interior surface thereof to engage the openings of the capsule. The coupler includes retention arms configured to engage a corresponding portion of an applicator. When a pre-determined compressive force is applied to the coupler, the deployment arms are proximally slidable along the corresponding portion of the applicator to deflect the deployment arms out of engagement with the capsule so that the coupler is separable from the capsule.

A device for treating tissue includes a clip including clip arms and a coupler. Each of the clip arms extends from a proximal end to a distal end. Proximal ends of the clip arms are slidably received within a channel of a capsule. A proximal end of the capsule includes openings extending through a wall. The coupler is mounted over the proximal end of the capsule via deployment arms including engaging features extending laterally inward from an interior surface thereof to engage the openings of the capsule. The coupler includes retention arms configured to engage a corresponding portion of an applicator. When a pre-determined compressive force is applied to the coupler, the deployment arms are proximally slidable along the corresponding portion of the applicator to deflect the deployment arms out of engagement with the capsule so that the coupler is separable from the capsule.

The application relates to a heart valve clamp, comprises a fixed arm mechanism, a clamping arm mechanism, and a driving mechanism. The fixed arm mechanism comprises a fixed arm body and at least two fixed arms, extending outward from the fixed arm body, and integrally formed with the fixed arm body. The clamping arm mechanism comprises a clamping arm body connected to a bottom of the fixed arm body, and at least two clamping arms extending outward from the clamping arm bodies and integrally formed with the clamping arm body; and the driving mechanism comprises a second driving assembly that drives the fixed arm and the clamping arm to open or close. The fixed arm mechanism and the clamping arm mechanism of the entire heart valve clamp respectively forms an integral form, which can avoid the risk of the fixed arm or the clamping arm being disengaged, the stability of the whole structure is better. The fixed arm and the clamping arm clamp the valve leaflets under three-dimensional ultrasound and angiography navigation, so that the regurgitation area is reduced, which is capable of treating mitral or tricuspid regurgitation while keeping heat beating.

A tissue clip application fitting set or retrofitting set includes a cap attachment for placement on the distal head of a medical endoscope, which has a placement section and a tissue clip holding section. The cap attachment is notched at least at two angular positions forming at least two notches/slots/grooves. A working channel leads into the hollow chamber and exits the hollow chamber radially in a region distal to the placement section and proximal to the radially supported tissue clip. A first guiding or leading element is arranged after the working channel belonging to the retrofitting set, as seen in the distal direction. A corresponding second guiding or leading element is arranged within the hollow chamber at an angular distance from the first guiding or leading element so as to be oriented in extension to a working channel belonging to the endoscope.

A tissue clip application fitting set or retrofitting set includes a cap attachment for placement on the distal head of a medical endoscope, which has a placement section and a tissue clip holding section. The cap attachment is notched at least at two angular positions forming at least two notches/slots/grooves. A working channel leads into the hollow chamber and exits the hollow chamber radially in a region distal to the placement section and proximal to the radially supported tissue clip. A first guiding or leading element is arranged after the working channel belonging to the retrofitting set, as seen in the distal direction. A corresponding second guiding or leading element is arranged within the hollow chamber at an angular distance from the first guiding or leading element so as to be oriented in extension to a working channel belonging to the endoscope.