Provided herein are methods and compositions for treating bone osteonecrosis comprising: at least one of a Gelatin tyramine (GT), a gelatin-heparin tyramine (GHT), a gelatin methacryloyl (GelMa), a gelatin acryloyl (GelAC), collagen, or a hydrogel-forming peptide that can be formed ex vivo or in situ for the treatment of bone osteonecrosis; at least one bone growth promoting agent or a macrophage depletion reagent; and optionally one or more pharmaceutically acceptable carriers.

A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

A depth limiter configured for use with a surgical cannula includes an annular base having a boss that extends about a longitudinal axis and has a boss lumen configured to receive the surgical cannula. A latch arm coupled with the annular base overlies the boss and includes an arm opening configured to align with the boss lumen to receive the surgical cannula. The latch arm is movable relative to the annular base between a release position and a lock position. In the release position the arm opening is positioned coaxially with the boss lumen such that the latch arm is configured to permit longitudinal movement of the depth limiter along the surgical cannula. In the lock position the arm opening is positioned non-coaxially with the boss lumen such that the latch arm is configured to inhibit longitudinal movement of the depth limiter along the surgical cannula.

Meniscal repair devices, systems, and methods are provided.

There is provided a medical needle with a protector that allows separately molded hub and protector to be easily assembled together. A medical needle with a protector (1) includes: a hub (3) that supports a needle tube (2); a protector (4) capable of storing the needle tube (2); a first lock unit (42a, 42b, 73) that locks the hub (3) to the protector (4) capable of unlocking in a first state; and a second lock unit (43, 75) that locks the hub (3) to the protector (4) incapable of a transition to the first state in a second state. The protector includes a large cylindrical portion (41), a protrusion piece (43), and a width-increased portion (42). The width-increased portion (42) is provided on the outer peripheral side of the protrusion piece (43) and has a minor axis and a major axis. The protrusion piece (43) is formed integrally with the large cylindrical portion (41) on the major axis side of the width-increased portion (42).

The various inventions relate to robotic surgical devices, consoles for operating such surgical devices, operating theaters in which the various devices can be used, insertion systems for inserting and using the surgical devices, and related methods.

A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

A device comprises an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. Each of a first subset of the ultrasound probes is positioned such that a direction of ultrasound waves generated thereby is through a body side of the ultrasound probe housing and perpendicular thereto. Each of a second subset of the ultrasound probes is positioned non-perpendicular to the body side of the ultrasound probe housing such that a direction of ultrasound waves generated thereby is toward a site of needle penetration directly beneath a guide channel cut-out or aperture of the ultrasound probe housing. A first ultrasound probe in the first subset of ultrasound probes may be located further from the body side of the ultrasound probe housing that a second ultrasound probe in the first subset of ultrasound probes.

A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.