Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end is disclosed, as well as therapies for joint and cartilage repair, preservation and generation using it. Alternatively, for disc repair, a “PIARES” device for Percutaneous Intradiscal Annular Repair introduces therapeutics intradiscally. The device may have two-needles; a first cannula/needle with a finger grip, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system; using it minimizes trauma.

An access and radio-frequency (RF) ablation system and method for use thereof is provided. The access and RF ablation system can include an RF ablation probe, a stylet, a cannula, a needle, and a drill. The method of using the access and radio-frequency ablation system can include inserting portions of a combined stylet into a patient's body to create a pathway therethrough and position a distal end of the stylet and a distal end of the cannula adjacent hard and/or soft tissues requiring ablation or tissues adjacent thereto; pushing portions of the needle into, through, and out of an interior cavity of the cannula to position a curved distal end of the needle adjacent the distal end of the cannula in the pathway; lengthening the pathway in an angled and curved direction relative to a mid-longitudinal axis of the cannula by pushing the curved distal end portion of the needle further into the hard and/or soft tissues requiring ablation or the tissues adjacent thereto; guiding a drill using the needle to enlarge and/or further lengthen the pathway in the hard and/or soft tissues requiring ablation or the tissues adjacent thereto in an angled and curved direction relative to the mid-longitudinal axis of the cannula; pushing portions of the RF ablation probe into, through, and out of the cannula and into and through the pathway to position a distal end portion of the RF ablation probe adjacent the hard and/or soft tissues requiring ablation; and activating the RF ablation probe to ablate all or portions of the hard and/or soft tissues requiring ablation.

Methods for creating a void within a bone. An elongate member is directed into a tube of an access cannula, and a handle is positioned adjacent the access cannula. A working tip and pre-bent elbow are disposed within the tube such that the pre-bent elbow is straightened. The device remains slidable relative to the access cannula. A control assembly is actuated to distally move the shaft relative to the handle. Bone adjacent the tube of the access cannula may resist the working tip from protruding from the access cannula so as to displace the handle of the device proximally, or the handle may be manually maintained adjacent the access cannula. The pre-bent elbow and the working tip are moved beyond the distal end of the tube to be freed from the constraint of the tube of the access cannula to assume a curve within the bone.

A bone fusion system including a collection vessel, an abrading and harvesting device, tubing and a probe. The abrading and harvesting device includes a needle portion and a sharpened tip. The needle portion has a central bore extending therethrough. The needle portion has a distal end. The sharpened tip is attached to the distal end of the needle portion. The tubing is operably connecting the collection vessel and the abrading and harvesting device. The probe has a threaded portion and a tip portion at a distal end of the threaded portion. The threaded portion has a thread on an outer surface thereof. The tip portion is unsharpened and does not have a thread on an outer surface thereof. The probe is extendible through the central bore.

An intraosseous device comprises a stylet with a pointed end for penetrating bone and a cannula through which the stylet extends. The stylet has a bent portion which is engaged in a receiver in a handle cover. The cannula has an outwardly extending flare which is engaged in a corresponding seat in a hub. The handle and the hub have formations which interlock with one another when the tip of the stylet is aligned with the tip of the cannula. The interlock formations further assist torque transmission. The configuration ensures that the maximum manual torque can be applied to penetrate bone whilst ensuring that the stylet and cannula are aligned for maximum cutting efficiency and remain fixed to the handle and the hub respectively.

The present disclosure relates to methods and compositions for the treatment of degenerate bone in a patient. In some embodiments, the methods and compositions disclosed herein are useful in the treatment, prevention, or in delaying the progression of a bone disease linked to bone degeneration, such as osteoarthritis (“OA”), rheumatoid arthritis, and avascular necrosis.

A portable and passive safety intraosseous device to allow for direct introduction of medications, etc., within the intermedullary space of a subject patient's bone or, if needed, the removal of certain substances from such a subject patient's bone. Such a device permits direct drilling and placement of a cannula within the subject bone with access external to the subject patient's skin, permitting, as well, connection of a tube for such introduction/removal purposes. The ability to provide a passive safety unit allows for facilitated utilization in, for instance, emergency situations with the entire device provided for utilization thereof. The device includes a drilling component with a permanently attached stylet and a removable cannula, a power supply for a single drilling operation, a mechanism to draw the stylet back into the drill component after use and disengagement from the cannula, and an automatic closure that activates with the separation of the cannula.

An intraosseous access system to access a medullary cavity includes a driver including an access assembly, a motor, and an energy source. The intraosseous access system further includes a sensor configured to detect a first input from one of the motor or the energy source. The intraosseous access system further including a processing unit, communicatively coupled with the sensor, configured to receive the first input from the sensor, and determine access to a medullary cavity. The processing unit can then modify operation of one of the motor and the energy source to automatically stop operation of the system and prevent backwalling.

A cannula device for removing, including by aspirating, bodily material is disclosed. The device may include a cannula and a hub. The cannula includes an open proximal end and a deflectable distal segment, and one or a plurality of distal orifices fluidly connected to the lumen. When distally extended from an outer guide cannula, the deflectable segment assumes a curved shape, which includes temperature-dependent curvature subject to elevated temperature along a memory metal length of the cannula.

A bone graft delivery system includes a bone graft injector and an access portal. The access portal may include a handle having a first arm pivotably connected to, and biased away from, a second arm. A ratchet including a pawl may extend from the second arm. A delivery tube may be configured to mate with the first arm and be configured to store a bone graft material therein. A plunger including a shaft and a plunger tip at the distal end thereof may be configured to move through the delivery tube. At least a portion of the shaft may include teeth, the pawl of the ratchet being configured to iteratively contact the teeth. A user may hold the access portal with a first hand and the bone graft injector with a second hand, iteratively squeezing the handle to iteratively eject amounts of bone graft material into a patient.