Systems, devices, and methods are provided for transseptal access of septa within a patient. The device can be advanced to a septum, e.g., towards a fossa ovalis. Instead of applying positive pressure to “tent” the septum, a negative pressure is applied to a lumen within a sheath, e.g., within an elongated member slidable within the sheath, via a negative pressure source such as a syringe on the proximal end of the sheath. This results in the septum pulling inward. The sheath employs a stationary needle-like central core component contained within the lumen of the sheath that punctures the septum when the same is pulled passed it by the negative pressure. The stationary needle-like central core component may be hollow and may form a portion of the elongated member or may be coupled to a distal end thereof.

The invention provides systems, devices, and methods for the delivery, deployment, and positioning of magnetic compression devices at a desired site so as to improve the accuracy of anastomoses creation between tissues, organs, or the like.

A shunt device is configured to be inserted into a puncture in a tissue wall that defines a horizontal reference plane. The shunt device includes a shunt body. The shunt body includes a central flow tube extending from a first axial end to a second axial end and defining a central axis therethrough that is angled from a reference axis extending perpendicular through the horizontal reference plane; a flow path extending through the central flow tube; and a plurality of arms extending outward from the central flow tube and configured to secure the shunt device to the tissue wall. The plurality of arms includes a first distal arm and a second distal arm attached to the first axial end of the central flow tube and a first proximal arm and a second proximal arm attached to the second axial end of the central flow tube.

A surgical system and method for manipulating tissue. A steerable assembly comprises a steerable instrument and a deformable conduit. The steerable instrument comprises a control element and a deflectable portion operatively connected to the control element. The steerable assembly is directed through an access cannula such that at least a portion of the steerable assembly protrudes from the distal end of the access cannula. The steerable instrument is actuated to move a deflectable portion of the steerable instrument and a distal portion of the deformable conduit away from the longitudinal axis of the access cannula so that the deformable conduit assumes a deformed position. The steerable instrument is retracted from the deformable conduit.

An apparatus includes a first shaft extending distally from a proximal end to a distal end. The first shaft is sized to fit within an esophagus of a patient. The first shaft includes a first shaft lumen extending distally to the distal end. The apparatus further includes a second shaft slidably positioned within the first shaft lumen. The second shaft is sized to fit within the shaft lumen and extend through the transverse bore. The second shaft is configured to receive a guide element and a sphincter augmentation device so that the sphincter augmentation device may be deployed through an interior of the esophagus to an exterior of the esophagus.

In the biopsy system according to one embodiment, the needle tube of the treatment tool has the minor axis of the flattened portion and the bending plane of the bending portion parallel to each other. Accordingly, the needle tube is easily bent in the bending direction of the bending portion, and even in an endoscope that has few bendable directions and is bendable, for example, in only two directions (e.g., up and down), the bending operation of the bending portion is not easily hindered. As a result, even after the treatment tool for endoscopes is inserted into the endoscope, the bending portion can be easily bent with a predetermined bending amount, and a procedure can be easily performed.

An obesity treatment apparatus comprises at least one operable stretching device (10) implantable in an obese patient and adapted to stretch a portion (12a) of the patient's stomach wall (12), and an operation device (16, 18) for operating the stretching device when implanted to stretch the stomach wall portion such that satiety is created.

Transcatheter heart valve delivery systems having a tip assembly configured to close the hole or perforation made in a patient's septal wall after transseptal delivery of a stented prosthetic heart valve to a defective heart valve (e.g., a mitral valve). The delivery device is configured to permit in vivo release of the tip assembly immediately after deployment of the stented prosthetic heart valve to implant the tip assembly into the septal wall proximate the hole through which the stented prosthetic heart valve is delivered. Methods of treating the defective heart valve, including closing the hole made during transseptal delivery of the stented prosthetic heart valve with the tip assembly of the delivery device are also disclosed.

A method for treating or diagnosing cancer with and endosurgical device comprising at least two lengthwise extending channels (2,3,4,5; 2′,3′,4′,5′), two opposite jaws (9,10;9′,10′;9″,10″) with use of diathermy and flushing a tissue specimen to a proximal end of the endosurgical device. The method allows the surgeon to take several tissue specimens from an organ and to perform several functionalities when the device is inside the organ. The endosurgical device for use in the method is also disclosed.

This disclosure is for an endoluminal delivery cannula, for delivery of a substance to an extravascular target site via the vascular system of a human or animal body, wherein the cannula comprises a proximal cannula hub, an elongated proximal, and a tip portion. The tip is tapered towards the distal tip which is preferably provided with a pointed tip for penetrating tissue. The pointed tip may comprise at least one primary facet and two secondary facets, wherein the two secondary facets are arranged proximally of said primary facet. An endoluminal delivery assembly comprises the cannula, a protective catheter adapted for insertion into the vascular system of a human or animal body, and a proximal catheter hub provided at the proximal end of the catheter and adapted for guiding the catheter through the vascular system.