Exemplary embodiments of the present disclosure relate to devices, systems, and methods for tissue resection in a body lumen of a patient, and may include an elongate body having a cavity at a distal end and a tissue retractor extendable distally from the distal end of the elongate body. The tissue retractor may include an expansion mechanism. The expansion mechanism may include a plurality of arms each having a first end coupled around a distal cap and expandable radially outward from the distal cap such that an anchoring mechanism on a second end of the arms is engageable with selected tissue for resection of the body lumen. The tissue resection device may further include a tissue resecting device.

Systems, methods and devices for the treatment of tissue are disclosed. A system includes an elongate tube with a distal portion. A treatment element is positioned on the elongate tube distal portion, the treatment element constructed and arranged to treat target tissue. In one embodiment, gastrointestinal tissue is modified for the treatment of diabetes.

Various embodiments of bulking or cushioning agents or material and related medical devices and methods are disclosed. For example, a method of performing a medical procedure in a tract of a body may include injecting a material in a liquid phase proximate a target site between a first tissue layer and a second tissue layer, allowing the material to transition from the liquid phase to the gel phase in response to a raise in temperature of the material to approximately at or above the predetermined temperature, and performing a surgical procedure on the target site. The material may have the liquid phase at temperatures below a predetermined temperature and a gel phase at temperature approximately at or above the predetermined temperature.

A needle assembly 10 compromising an infusion needle 11 that includes a needle cannula 13 made of a superelastic material such as Nitinol. The needle cannula is cold-worked or heat annealed to produce a preformed bend 16 that can be straightened within passageway 21 of a coaxial outer cannula 12 for introduction into the body of a patient. Upon deployment from the outer cannula, the needle cannula substantially returns to the preformed configuration for the introduction or extraction of materials at areas lateral to the entry path of the needle assembly. The needle assembly can compromise a plurality of needle cannulae than can be variably arranged or configured for attaining a desired infusion pattern.

A safety neural injection system includes at least a partially hollow cannula having an inside diameter, an outside diameter, a first length, a side port located coaxially along the hollow cannula for fluid communication between the inside and the outside of the hollow cannula, and an open distal end. The safety neural injection system also includes a flexible stylet with a shaped tip. The flexible stylet is capable of being releasably locked in a position within the hollow cannula and extends at least the first length of the hollow cannula. The hollow cannula proximate to the distal end includes a rigid bend so as to facilitate placement of the distal end at the treatment site.

Method and system for treating a patient using an inflatable device. A removal device may be used to remove the inflatable device from the body. The removal device can have at least one manually-actuatable member and at least two opposing jaws at a distal end. At least one of the at least two jaws can be movable by actuation of the at least one manually-actuatable member. At least one of the at least two jaws can have a puncturing member.

A medical device is provided. The medical device includes a puncture needle that is inserted into body tissue from outside a body and pierces membranous tissue near pulsating tissue inside the body tissue; a tubular protection member that is disposed on the outer side of the puncture needle; a pulse-information acquisition portion that acquires pulse information of the pulsating tissue; and a driving unit that moves the puncture needle and the protection member relative to each other in synchronization with the pulse information of the pulsating tissue acquired by the pulse-information acquisition portion, in such a manner that a tip of the puncture needle is retracted toward a proximal end from a distal end of the protection member when the pulsating tissue expands and that the tip of the puncture needle is projected farther forward from the distal end of the protection member when the pulsating tissue contracts.

A cannula and needle assembly configured to first have the needle assembly create an opening in the skin of a person or animal and to then insert the cannula through the needle into the person or animal by way of the opening created by the needle. The assembly also includes structure to yieldably maintain the needle assembly in a docked position.

Systems and methods for treating gastroesophageal reflux disease (GERD) includes minimally invasively implanting a stimulating device in a patient's esophagus in the region proximate the lower esophageal sphincter (LES). The patient is provided with a questionnaire related to his disease via an online service. The questionnaire is accessed on a mobile device, such as a cell phone, or on a computer with network access. The data from the sensors and the answers from the questionnaire are analyzed together by a health care provider using the online service. The data and answers are used to program the stimulating device, via the mobile device or computer, to optimize treatment.

A robotic catheter device cartridge may include a finger or a slider block generally disposed in a channel and engaged with a steering wire. The steering wire may control movement of a component having the steering wire engaged thereto when the finger or the slider block is linearly driven in a predetermined direction. The cartridge may be a transseptal cartridge having a transseptal needle connected thereto, a catheter cartridge having a catheter connected thereto, or a sheath cartridge having a sheath connected thereto.