A personal care composition comprising N-aralkylcarbonyldiamines. When such compounds are used in personal care compositions, they have been unexpectedly shown to enhance cell proliferation and epidermal thickness, traits associated with younger, healthy looking skin.

Disclosed herein are compounds of formula I: ##STR00001##
and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.

Disclosed herein are compounds of formula I: ##STR00001##
and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.

Provided are compounds of Formula I:

##STR00001##

and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are as described herein. The compounds of Formula I are agonists of the kappa opioid receptor and relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

Provided are compounds of Formula I:

##STR00001##

and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are as described herein. The compounds of Formula I are agonists of the kappa opioid receptor and relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

The present invention provides compounds, compositions thereof, and methods of using the same.

A process of dissolving

##STR00001##

in a solvent to produce a first mixture. To the first mixture a reagent is added to produce a second mixture. A HNRR is then added to the second mixture to produce a third mixture. The third mixture is then refluxed to produce

##STR00002##

A process of dissolving

##STR00001##

in a solvent to produce a first mixture. To the first mixture a reagent is added to produce a second mixture. A HNRR is then added to the second mixture to produce a third mixture. The third mixture is then refluxed to produce

##STR00002##

The invention relates to compounds that have an affinity to the -opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.