A method for treatment of breast cancer using molecular profiling. The method comprises performing a molecular analysis of target breast cancer cells, identifying markers associated with the target breast cancer cells based on the performed molecular analysis, selecting on a graphical user interface of a cold atmospheric plasma generator the identified markers associated with the target breast cancer cells, selecting with a processor in the cold atmospheric plasma generator preferred cold atmospheric plasma settings associated with the identified markers in a database stored in a storage in the cold atmospheric plasma generator, and applying cold atmospheric plasma with the cold atmospheric plasma generator at the selected cold atmospheric pressure settings to the target breast cancer cells.

Embodiments include devices and methods configured to fractionally resect skin and/or fat. Fractional resection is applied as a stand-alone procedure in anatomical areas that are off-limits to conventional plastic surgery due to the poor tradeoff between the visibility of the incisional scar and amount of enhancement obtained. Fractional resection is also applied as an adjunct to established plastic surgery procedures such as liposuction, and is employed to significantly reduce the length of incisions required for a particular application. The shortening of incisions has application in both the aesthetic and reconstructive realms of plastic surgery.

In some aspects, the present disclosure pertains to methods of treating a tissue volume comprising (a) administering an implantable composition comprising a releasable membrane-active agent to a target site such that the membrane-active agent is locally released to the tissue volume and (b) performing irreversible, reversible and/or thermal treatment by application of a pulsed electric field to the tissue volume. In other aspects, the present disclosure pertains to embolic compositions that comprise releasable membrane-active agents.

An embodiment in accordance with the present invention provides a handheld cryoprobe for use in percutaneous cryotherapy of tumorous masses. It includes a probe attached to a CO.sub.2 gas dispensing backend. The probe has specifically optimized parameters designed for use with CO.sub.2 gas and is made out of a partially hollowed and threaded aluminum rod providing maximum heat exchange. The system backend regulates flow of compressed CO.sub.2 gas while throttling and cooling the gas coolant to the cytotoxically low temperatures necessary for targeted tumor cell death. Additionally, the incoming initial stream of CO.sub.2 gas is throttled by the Joule-Thomson nozzle on the backend. The low temperature exhaust gas is then used to pre-cool all subsequent incoming gas, resulting in an even lower temperature at the probe tip, which provides a positive feedback loop, continually decreasing the gas's temperature. The temperature drop is caused by the Joule-Thomson effect.

A medical imaging system comprising: a microwave antenna array comprising a transmitting antenna and a plurality of receiving antennae, wherein the transmitting antenna is configured to transmit microwave signals so as to illuminate a body part of a patient and the receiving antennae are configured to receive the microwave signals following scattering within the body part; a processor configured to process the scattered microwave signals and generate an output indicative of the internal structure of the body part to identify a target within the body part; and an ablation probe comprising an ablation needle movable relative to the microwave antenna array; wherein the receiving antennae are further configured to receive microwave signals scattered or emitted by the ablation needle and the processor is further configured to monitor a position of the ablation needle and to guide the ablation needle to the identified target within the body part which it can be used to perform an ablation procedure.

The present invention is an ablation device having a screen sphere configuration for the ablation of marginal tissue surrounding a tissue cavity. The device includes a probe having a nonconductive elongated shaft including at least one lumen therethrough and a nonconductive distal portion extending from the shaft. The nonconductive distal portion includes a plurality distal ports and a plurality of proximal ports in communication with the at least one lumen of the shaft. The device further includes an electrode array including a plurality of independent conductive wires extending through the lumen and positioned along an external surface of the nonconductive distal portion, each of the plurality of wires passes through at least an associated one of the proximal ports and through at least a corresponding one of the distal ports.

The present invention relates to a device for inducing migration of cancer cells for cancer treatment, comprising an RF absorber including an antenna for irradiating a frequency of a specific band to a living tissue including cancer cells; a method for inducing migration of cancel cells using the same; and a method for cancer treatment.

Methods and systems for delivering a cryogenic fluid to an inner surface of a surgical excision cavity, such as following breast tumor removal, are described. A single or dual balloon configuration can be utilized to deliver a cryogenic fluid to necrose tissue surrounding the tumor cavity in order to reduce the risk of recurrence of the cancer. The balloon can be optimally configured for maximum contact with the breast tumor bed.

A method for fusion of live ultrasound imagery with computed tomography (CT) scan images or magnetic resonance images, the method comprising steps of acquiring a series of CT scan images or magnetic resonance images, acquiring a series of ultrasound images, applying a manual registration process on a computing device to register each of the CT scan images or magnetic resonance images with corresponding ultrasound images, and displaying on a display associated with the computing device the live ultrasound imagery and corresponding CT scan images or magnetic resonance images.

The device (1; 5) comprises: a protective cannula (7); a tubular suction member (9) coaxially housable in the protective cannula (7); a catheter (21), coaxially housable in the tubular suction member (9) and adapted to internally contain an optical fiber (23). The catheter is equipped, at a distal end (21 A) thereof, with an expandable balloon (25) adapted to be expanded by means of a fluid delivered through the catheter (21). The protective cannula (7) is axially movable with respect to the tubular suction member (9) and to the catheter (21).