The invention provides compounds of the formula (3):

##STR00001## or a pharmaceutically acceptable salt or tautomer thereof, wherein: Z is a 5-membered heteroaryl ring containing one or two nitrogen ring members and optionally one further heteroatom ring member selected from N and O; ring X is a benzene or pyridine ring; ring Y is a benzene, pyridine, thiophene or furan ring; Ar.sup.1 is an optionally substituted benzene, pyridine, thiophene or furan ring; m is 0, 1 or 2; n is 0, 1 or 2; R.sup.1 is selected from various substituents: R.sup.2 is selected from hydrogen and a C.sub.1-4 hydrocarbon group; R.sup.3 is selected from hydrogen and a C.sub.1-4 hydrocarbon group; R.sup.4 is selected from various substituents; R.sup.5 is selected from various substituents; Ar.sup.2 is an optionally substituted phenyl, pyridyl or pyridone group; R.sup.6 is a group Q.sup.1-R.sup.a—R.sup.b; Q.sup.1 is absent or is a C.sub.1-3 saturated hydrocarbon linker; R.sup.a is selected from O; C(O); C(O)O; CONR.sup.c; N(R.sup.c)CO; N(R.sup.c)CONR.sup.c, NR.sup.c; and SO.sub.2NR.sup.c; R.sup.b is selected from hydrogen and various substituents; and R.sup.b is selected from R.sup.4. The compounds are useful in the treatment of cancers.

The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.

##STR00001##

The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.

##STR00001##

This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including cyclic and heterocyclic anilide rings and their synthetic precursors, and mono-, di-, or multi-substituted N-heterocyclic rings, R-isomers, non-hydroxylated and/or non-chiral propanamides in treating androgen receptor dependent diseases and conditions such as hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

The present invention relates to pyrazole derivatives of formula (X)

##STR00001## wherein ring A is a pyrazole and substituents R.sup.B1, R.sup.B2, n, R.sup.Q1, R.sup.Q2, R.sup.Q3, and R.sup.Q4 are as defined in claim 1, their manufacture, and their use in the manufacture of agrochemicals and pharmaceuticals.

The present invention relates to pyrazole derivatives of formula (X)

##STR00001## wherein ring A is a pyrazole and substituents R.sup.B1, R.sup.B2, n, R.sup.Q1, R.sup.Q2, R.sup.Q3, and R.sup.Q4 are as defined in claim 1, their manufacture, and their use in the manufacture of agrochemicals and pharmaceuticals.

The present disclosure provides compounds of formula (II)

##STR00001##

and compositions/methods of use thereof.

The present disclosure provides compounds of formula (II)

##STR00001##

and compositions/methods of use thereof.

The present invention relates to an adduct comprising metal particles and an adduct between an sp2 carbon allotrope and a pyrrole compound. In particular, the invention relates to an adduct comprising metal nanoparticles (NPs) and hydrophylic adducts between a sp2 carbon allotrope and a pyrrole compound. The metal preferentially copper, silver or gold. Such adduct is preferentially used for anti-bacterial activity.

The present invention relates to an adduct comprising metal particles and an adduct between an sp2 carbon allotrope and a pyrrole compound. In particular, the invention relates to an adduct comprising metal nanoparticles (NPs) and hydrophylic adducts between a sp2 carbon allotrope and a pyrrole compound. The metal preferentially copper, silver or gold. Such adduct is preferentially used for anti-bacterial activity.