Patent classifications
C07D213/54
Compounds and compositions for the inhibition of NAMPT
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA. ##STR00001##
MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
Pyridin-2-yl alkylamino substituted hydroxamic acid and uses thereof
Compounds of formula I are provided: ##STR00001##
wherein X is NH, or CH.sub.2, Y is a single bond, or —CHR.sub.5—, R.sub.1 is H, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 hydroxyalkyl, R.sub.2 and R.sub.2′ are each independently H, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 hydroxyalkyl, each R.sub.3 is independently H, halo, —CF.sub.3, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 alkoxy, C.sub.3 perhaloalkyl, each R.sub.4 is independently H, halo, or C.sub.1-C.sub.4 alkyl, R.sub.5 is C.sub.1-C.sub.4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.
Pyridin-2-yl alkylamino substituted hydroxamic acid and uses thereof
Compounds of formula I are provided: ##STR00001##
wherein X is NH, or CH.sub.2, Y is a single bond, or —CHR.sub.5—, R.sub.1 is H, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 hydroxyalkyl, R.sub.2 and R.sub.2′ are each independently H, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 hydroxyalkyl, each R.sub.3 is independently H, halo, —CF.sub.3, C.sub.1-C.sub.4 alkyl, or C.sub.1-C.sub.4 alkoxy, C.sub.3 perhaloalkyl, each R.sub.4 is independently H, halo, or C.sub.1-C.sub.4 alkyl, R.sub.5 is C.sub.1-C.sub.4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.
SMALL MOLECULE MODULATORS OF THE BTB DOMAIN OF KEAP1
The present application relates to compounds of formula (I) or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington disease (HD) and other CAG-triplet repeat (or polyglutamine) diseases, amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease), diffuse Lewy body disease, chorea-acanthocytosis, primary lateral sclerosis, multiple sclerosis (MS), frontotemporal dementia, Friedreich's ataxia, acute head injury, and epilepsy (repression of microglia activation).
MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
##STR00001##
NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
##STR00001##
NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
##STR00001##