The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I) ##STR00001## in which X.sup.1, X.sup.2, X.sup.3, X.sup.4, R.sup.1, R.sup.2, R.sup.3, n have the meanings given in the descriptionto their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation.

The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I) ##STR00001## in which X.sup.1, X.sup.2, X.sup.3, X.sup.4, R.sup.1, R.sup.2, R.sup.3, n have the meanings given in the descriptionto their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation.

The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.

The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.

A compound represented by formula (4) is produced by a step A of reacting a compound represented by formula (2): ##STR00001##
wherein R.sup.1 represents an ethyl group or the like, R represents a halogen atom or the like, n represents 0, 1, 2, or 3, and M represents potassium or the like, with thionyl chloride to obtain a compound represented by formula (1): ##STR00002##
a step B of reacting the compound represented by formula (1) with a compound represented by formula (5): ##STR00003##
wherein A.sup.1 represents a nitrogen atom or CH, R.sup.5 represents a trifluoromethyl group or the like, and m represents 1 or 2, to produce a compound represented by formula (3): ##STR00004##
or an acid salt thereof; and a step C of reacting the compound represented by formula (3) or an acid salt thereof in the presence of acid at 100 C. to 180 C. to obtain the compound represented by formula (4): ##STR00005##

A compound represented by formula (4) is produced by a step A of reacting a compound represented by formula (2): ##STR00001##
wherein R.sup.1 represents an ethyl group or the like, R represents a halogen atom or the like, n represents 0, 1, 2, or 3, and M represents potassium or the like, with thionyl chloride to obtain a compound represented by formula (1): ##STR00002##
a step B of reacting the compound represented by formula (1) with a compound represented by formula (5): ##STR00003##
wherein A.sup.1 represents a nitrogen atom or CH, R.sup.5 represents a trifluoromethyl group or the like, and m represents 1 or 2, to produce a compound represented by formula (3): ##STR00004##
or an acid salt thereof; and a step C of reacting the compound represented by formula (3) or an acid salt thereof in the presence of acid at 100 C. to 180 C. to obtain the compound represented by formula (4): ##STR00005##

Provided are compounds of Formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Provided are compounds of Formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

A novel guanidine compound having excellent fungicidal activity is represented by formula [I]. (In the formula, Y represents a divalent group represented by formula [II] (wherein each of R.sup.7-R.sup.9 independently represents a hydrogen atom or the like) or the like; each of X and Z independently represents an unsubstituted or substituted alkylene group or the like; each of Q.sup.1 and Q.sup.2 independently represents a single bond or the like; each of A.sup.1 and A.sup.2 independently represents an unsubstituted or substituted divalent heterocyclic compound residue or the like; and each of R.sup.1-R.sup.6 independently represents a hydrogen atom or the like.)

##STR00001##

A novel guanidine compound having excellent fungicidal activity is represented by formula [I]. (In the formula, Y represents a divalent group represented by formula [II] (wherein each of R.sup.7-R.sup.9 independently represents a hydrogen atom or the like) or the like; each of X and Z independently represents an unsubstituted or substituted alkylene group or the like; each of Q.sup.1 and Q.sup.2 independently represents a single bond or the like; each of A.sup.1 and A.sup.2 independently represents an unsubstituted or substituted divalent heterocyclic compound residue or the like; and each of R.sup.1-R.sup.6 independently represents a hydrogen atom or the like.)

##STR00001##