Described here are methods and systems for the manipulation of ovarian tissues. The methods and systems may be used in the treatment of polycystic ovary syndrome (PCOS). The systems and methods may be useful in the treatment of infertility associated with PCOS.

Ablation electrode assemblies include an inner core member and an outer shell surrounding the inner core member. The inner core member and the outer shell define a space or separation region therebetween. The inner core member is constructed from a thermally insulative material having a reduced thermal conductivity. In an embodiment, the space is a sealed or evacuated region. In other embodiments, irrigation fluid flows within the space. The ablation electrode assembly further includes at least one thermal sensor in some embodiments. Methods for providing irrigation fluid during cardiac ablation of targeted tissue are disclosed that include calculating the energy delivered to irrigation fluid as it flows within the ablation electrode assembly through temperature measurement of the irrigation fluid. Pulsatile flow of irrigation fluid can be utilized in some embodiments of the disclosure.

Neuromodulation catheter systems with controlled irrigation capabilities and methods for using such systems are disclosed herein. One such method includes, for example, positioning an irrigated neuromodulation catheter at a treatment site within a renal blood vessel of a human patient, delivering neuromodulation energy at the treatment site, and delivering irrigation fluid to the treatment site having characteristics coordinated with the delivered energy. The characteristics can be adjusted to maintain an energy delivery element and/or tissue of the blood vessel at a constant temperature as power is increased. The method can further include monitoring at least one parameter of the tissue and/or of the energy delivery element, and adjusting the neuromodulation energy and/or the characteristics of the irrigation fluid if the at least one parameter falls outside of a treatment range of values.

A method of treating a patient with a therapeutic laser pulse includes applying a cooling mechanism to a first skin area, cooling a target skin area within the first the skin area from a first surface temperature to a second temperature through application of the cooling mechanism prior to application of the therapeutic laser pulse, initiating application of the therapeutic laser pulse at a first timepoint, while continuing to apply the cooling mechanism, determining a surface temperature of the target skin area a plurality of times during application of the therapeutic laser pulse at a refresh rate of 25 Hz to 400 Hz, and terminating the application of the therapeutic laser pulse at a second timepoint, based on the surface temperature determinations. Each of the plurality of surface temperature determinations occurs during a single therapeutic laser pulse duration from the first time point to the second timepoint.

Aspects of the present disclosure are directed to, for example, a high-thermal-sensitivity ablation catheter tip. More specifically, various aspects of the present disclosure are directed to improved thermocouple response to temperature changes associated with an ablation electrode and/or tissue in contact therewith. Such an ablation catheter tip facilitates reduced lag in an ablation control system's response to the sensed temperature changes.

Pursuant to embodiments of the present invention, a method of performing electronically controlled electrotherapy may include modifying or killing target cells and simultaneously modifying a secondary outcome by delivering electrical pulses and dynamically adjusting an energy delivery profile of the electrical pulses in response to a measurement. The secondary outcome may be a physical outcome, a biological outcome, and/or a systemic outcome.

A tissue cutting probe includes an outer sleeve assembly, an inner sleeve assembly, a burr and an electrode. Each of the inner and outer sleeves has a proximal end, a distal end, and central passage extending therebetween. The inner sleeve assembly is coaxially and rotatably received in the central passage of the outer sleeve assembly, and the burr has a plurality of metal cutting edges carried on a first side of the distal end of the inner sleeve assembly. The electrode is carried a second side of the distal end of the inner sleeve assembly.

An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivering of multiple energies to enhance a visual appearance.

A method for performing an electrosurgical procedure at a surgical site on a patient includes continually sensing electrical and physical properties proximate the surgical site that includes acquiring readings of tissue electrical impedance with respect to time at the surgical site; identifying the minima and maxima of the impedance readings with respect to time; and correlating the minima and/or the maxima of the impedance readings with hydration level and/or hydraulic conductivity in the tissue at the surgical site. The method also includes controlling the application of electrosurgical energy to the surgical site to vary energy delivery based on the step of correlating the minima and/or the maxima of the impedance readings with the hydration level/or and the hydraulic conductivity in the tissue at the surgical site. The process may be an ablation process.

A method for adjusting the operation of a surgical instrument using machine learning in a surgical suite is disclosed. The method comprises the steps of gathering data during surgical procedures, wherein the surgical procedures include the use of a surgical instrument, analyzing the gathered data to determine an appropriate operational adjustment of the surgical instrument, and adjusting the operation of the surgical instrument to improve the operation of the surgical instrument.