The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.

The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.

A composition is provided that, when utilized in combination with a coumarin anticoagulant, greatly improves the anticoagulant effects of the anticoagulant in mammalian subjects. The composition is a compound having a naphthohydroquinone ring system substantially similar to the ring system of the reduced form of vitamin K.sub.1 and has the general formula:

##STR00001##

where n is 1 or 2, where R.sub.1 and R.sub.4 are hydrogen or acyl, R.sub.2 is a hydrogen or saturated or unsaturated alkyl group with up to 6 carbons, and R.sub.3 is a hydrogen or saturated or unsaturated alkyl group with up to 6 carbons, or R.sub.2 and R.sub.3 are part of a cyclic or polycyclic ring system.

A composition is provided that, when utilized in combination with a coumarin anticoagulant, greatly improves the anticoagulant effects of the anticoagulant in mammalian subjects. The composition is a compound having a naphthohydroquinone ring system substantially similar to the ring system of the reduced form of vitamin K.sub.1 and has the general formula:

##STR00001##

where n is 1 or 2, where R.sub.1 and R.sub.4 are hydrogen or acyl, R.sub.2 is a hydrogen or saturated or unsaturated alkyl group with up to 6 carbons, and R.sub.3 is a hydrogen or saturated or unsaturated alkyl group with up to 6 carbons, or R.sub.2 and R.sub.3 are part of a cyclic or polycyclic ring system.

The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.

The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.

The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.

The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.

The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.

The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.