A high temperature cryosurgery system and method of operation comprising a refrigeration assembly, a cryoprobe and a refrigerant wherein the cryoprobe and the refrigeration assembly are fluidly coupled in a closed loop configured to cycle the refrigerant in a fluid state from the refrigeration assembly to the cryoprobe and further configured to cycle the refrigerant in a vapor state from the cryoprobe to the refrigeration assembly. A method for treating cancer tumors and metastatic cancer cells by disrupting the tumor by sequentially or concurrently administering an ablative energy in combination with immunomodulation and/or pharmacological application, in one or more cycles, where the physical disruption is applied at levels sufficient to create the abscopal effect. That effect is generated by stimulating the immune cells in the microenvironment. The tumor is treated in a way permitting the remaining cells or elements in the tumor microenvironment to exert net immune stimulation with also long-term memory cells to fight subsequent appearing tumor in the future. Adding immune modulators injected in situ systemically or embedded in slow releasing means locally or systemically will boost the immune response to the cancer.

Devices, systems, and methods for treating cardiac arrhythmia are disclosed herein. In some embodiments, devices, systems, and methods disclosed herein deliver interrogating energy to tissue at a position on a wall of an anatomical structure of a patient. If the devices, systems, and methods disclosed herein detect a change in electrical activity of the anatomical structure in response to the interrogating energy, the devices, systems, and methods disclosed herein can apply irreversible therapy to the tissue. In some embodiments, the change in electrical activity corresponds to slowing or termination of a detected arrhythmia

A self-contained, battery powered transseptal crossing system is disclosed. An elongate, flexible electrically conductive needle body has a proximal end and a distal end. An insulation layer surrounds the sidewall and leaves exposed a distal electrode tip. A generator is configured to deliver RF energy to the electrode tip, and includes a processos configured to take impedance measurements at the tip to confirm contact with the intra atrial septum and / or confirm entry into the left atrium.

A surgical instrument comprising a rotatable and translatable firing member is disclosed.

Disclosed is a surgical instrument comprising an end effector with independently activatable segmented electrodes.

Disclosed is a method of adapting energy modality due to a short circuit or tissue type grasped in the jaws of an end effector of a surgical instrument. The method includes selecting an electrode in an array of segmented electrodes during a pre-energy activation cycle. The method includes applying a sub-therapeutic electrical signal to the selected electrode to differentiate between a shorted electrode and low impedance tissue grasped in the jaws of the end effector. The method includes determining the selected electrode is shorted based on a measured electrical parameter received by the control circuit after applying the sub-therapeutic electrical signal and blending monopolar and bipolar RF energy. The method includes determining that the selected electrode is shorted and switching output energy of the RF generator between monopolar and bipolar RF energy.

A knife limit for a surgical instrument includes a housing having a shaft extending therefrom configured to support an end effector at a distal end thereof, the end effector including first and second jaw members. One or both of the jaw members including a knife channel defined therein and extending therealong to a distal portion thereof. A knife assembly is disposed within the housing and cooperates with a trigger to translate a knife within the knife channel to the distal portion of the jaw member upon actuation thereof. A knife limit button is disposed within the housing and is configured to limit the distal translation of the knife within the knife channel upon selective actuation thereof. The knife limit button is movable between a first position allowing full translation of the knife within the knife channel and a second position limiting distal translation of the knife within the knife channel.

Control systems and methods for delivery of energy that may include control algorithms that prevent energy delivery if a fault is detected and may provide energy delivery to produce a substantially constant temperature at a delivery site. In some embodiments, the control systems and methods may be used to control the delivery of energy, such as radiofrequency energy, to body tissue, such as lung tissue.

A surgical system includes an end effector assembly having first and second jaw members, a generator, and one or more machine learning applications. The first and/or second jaw member is movable relative to the other from a spaced-apart position to an approximated position for grasping tissue therebetween. The jaw members are configured to conduct energy therebetween and through tissue grasped therebetween. The generator includes an energy output configured to supply energy to the jaw members, a main controller configured to control the energy output, and sensor circuitry configured to sense impedance and/or power. The machine learning application(s) is configured to determine a type of tissue grasped between the first and second jaw members based upon the impedance and/or power sensed by the sensor circuitry.

A monitoring equipment and a monitoring method thereof. The monitoring equipment includes: a treatment device (100) and a main control device (200). The treatment device (100) comprises a housing (110), a treatment surface (120) and an antifreeze film (130), and the treatment surface (120) is disposed between the housing (110) and the antifreeze film (130). The treatment device (100) further comprises a detection branch (150), the detection branch (150) comprises a current detection unit (151), and the current detection unit (151) is configured to detect a branch current (I0) of the detection branch (150). The treatment device (100) further comprises an electrode pair (140), and the electrode pair (140) is connected in parallel with the detection branch (150) and then connected to a constant voltage source. The main control device (200) is electrically connected to the treatment device (100).