A process for the preparation of a composition comprising amine-containing phosphate glycerides including: phosphorylating a solution which comprises mixed glycerides that contain fatty acid portions and an amine under conditions which are substantially water-free and under which said phosphorous pentoxide reacts with reactive constituents in said solution to form said amine-containing phosphate glycerides and a lubricating composition comprising a lubricant, the aforesaid composition in an amount which improves the properties of the lubricating composition, and optionally one or more other constituents which improve the properties of the lubricating composition.

There is provided phospholipid-peptide or phospholipid-protein conjugates useful for identification of autoantibodies, and in particular autoantibodies directed towards phospholipids. There is further provided intermediates and methods for their preparation as well as synthesis of the phospholipid-peptide or phospholipid-protein conjugates.

There is provided phospholipid-peptide or phospholipid-protein conjugates useful for identification of autoantibodies, and in particular autoantibodies directed towards phospholipids. There is further provided intermediates and methods for their preparation as well as synthesis of the phospholipid-peptide or phospholipid-protein conjugates.

The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

An object is to provide a polydimethylsiloxane-containing monomer that exhibits satisfactory compatibility with a hydrophilic monomer and a hydrophilic polymer, in which a polymerization product obtained by polymerizing a composition including the polydimethylsiloxane-containing monomer, the hydrophilic monomer, and the hydrophilic polymer has an anti-lipid adhesion property. It has been recognized that a polydimethylsiloxane-containing monomer having a phosphorylcholine group and a hydroxy group can achieve the object, and thus the present disclosure has been completed.

The present invention relates to novel biguanide derivatives including their pharmaceutically acceptable salts. The invention also relates processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions containing and the uses of such compounds in treating disorders such as diabetes.

Dihydrogen metaphosphate can be synthesized via protonation, and can react with a dehydrating agent to afford tetrametaphosphate anhydride. A monohydrogen tetra-metaphosphate organic ester can be derived from the anhydride. A metal tetrametaphosphate complex can be prepared using a metal salt and a dihydrogen tetrametaphosphate.

Embodiments described herein are directed to oligomeric phosphonates and polyphosphonates that have non-reactive end groups, methods for making such oligomeric phosphonates and polyphosphonates, and compositions containing such oligomeric phosphonates and polyphosphonates. The oligomeric phosphonates and polyphosphonates of such embodiments may be incorporated into engineering polymeric into which they are mixed to make polymer compositions having good flame retardancy and mechanical properties.

Embodiments described herein are directed to oligomeric phosphonates and polyphosphonates that have non-reactive end groups, methods for making such oligomeric phosphonates and polyphosphonates, and compositions containing such oligomeric phosphonates and polyphosphonates. The oligomeric phosphonates and polyphosphonates of such embodiments may be incorporated into engineering polymeric into which they are mixed to make polymer compositions having good flame retardancy and mechanical properties.

An artificial immune cell emulating certain properties of the granulocytes is disclosed as a construct or aggregate of several constituent particles that possess the properties of catalysis therefore producing free radicals and reactive species of oxygen, nitrogen, halogens and the like in the classical Fenton and Fenton-like reactions with produced free radicals serving as signaling molecules and, in higher concentrations, as toxic factors for microorganisms, cancerous cells, abnormal tissue and other biological targets, emulating the production of free radicals by natural immune cells. Motility of the artificial immune cell is facilitated by magnetotactic and other means, as some or all of the constituent particles possess magnetic, especially superparamagnetic properties which may be provided by the same catalytic components since said particles such as those containing compounds such as magnetite, maghemite, and substituted ferrites are capable of catalyzing Fenton-type reactions. Constituent particles of the artificial immune cell may be coated with agents facilitating specific targeting and binding such as antibodies to target antigenes, they may also interact with the intrinsically present natural immune cells by presenting antigens or antibody fragments. Other constituent particles of the artificial immune cell may be coated with lipid bilayers with sequestered biologically active molecules that are released as the lipid bilayer is destroyed by free radicals or they may contain cavities or internal spaces filled with biologically active molecules and capped or sealed with easily oxidizable materials facilitating the release of such molecules in the presence of aggressive oxidants such, thus emulating the property of granulocytes known as degranulation. A variety of the constituent particle may be a capped hollow cylinder with the internal walls presenting with excess of negative electric charges and filled with compacted nucleic acid-protein mixtures whereas upon destruction of the caps the repulsive electric force pushes out the nucleic acid-protein mixture emulating the property of neutrophils known as formation of neutrophil extracellular traps. Modification, modulation and termination of the activity of the artificial immune cell is accomplished by removal by magnetotactic locomotion, disruption with energetic waves, extinguishing of Fenton and Fenton-type reactions by introduction of reaction termination conditions such as excess of antioxidants. Additional refinements are disclosed with specific chemical and physical alterations of the constituent particles or the complete artificial immune cell.