A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.

Generally discussed herein are systems, devices, and methods for providing a therapy (e.g., stimulation) and/or data signal using an implantable device. Systems, devices and methods for interacting with (e.g., communicating with, receiving power from) an external device are also provided.

A portable cryogenic applicator includes a vessel for liquid nitrogen to deliver liquid nitrogen for treatment of skin surfaces using the rotating roller from porous biocompatible material. The cryogenic applicator includes a capillary U-bend to prevent spontaneous discharge of liquid nitrogen through the capillary system to the roller during filling or refilling the cryogenic applicator with liquid nitrogen. The cryogenic applicator also includes a vacuum valve that produce an insulating vacuum environment in a vacuum cavity to prevent heat transfer between the vessel for liquid nitrogen and a vacuum casing, which allows the external surface of the cryogenic applicator to be maintained at ambient temperature. The cryogenic applicator may include a control valve for regulating and maintaining the working pressure in the vessel for liquid nitrogen sufficient to deliver liquid nitrogen through the capillary system and the porous roller body to the surface skin of a patient.

Slurries comprise liquid water, about 2% to about 70% ice by volume, and one or more additives affecting flowability and/or tonicity of the slurry. Solutions for making a slurry comprise liquid water and one or more additives affecting flowability of the slurry. Flowability of the slurry relates to ice particles capable of flowing through a cannula, such as a needle. The slurry is suitable for injection into subcutaneous fat of a human subject for removal of adipose tissue.

The present disclosure is directed to a method of performing a photo-thermal dermatological procedure without use of an injectable anesthetic. The method includes applying a topical anesthetic to a treatment area of skin, measuring a surface temperature of the treatment area of skin, and passing a stream of cold air over the area of skin such that the surface temperature of the treatment area of skin is maintained between 0 degrees Celsius and 15 degrees Celsius for a duration of at least 30 seconds. The method further includes administering a photo-thermal energy dose to the area of skin after the duration.

The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to methods and devices to enhance radial spray from a catheter. Extension devices for a radial spray catheter, including radial cryospray catheters, are disclosed.

The illustrated embodiments include an apparatus to reduce or eliminate full thickness injury in tissue and to deform tissue which includes a probe or mechanism for deforming tissue, and a subsystem for selectively cooling and/or heating tissue while deformation is of the tissue is being performed. The illustrated embodiments of the invention also extend to a method to reduce or eliminate full thickness injury in tissue and to deform tissue including the steps of deforming tissue, and selectively cooling and/or heating tissue while deformation of the tissue is being performed.

Heads for an aerosol container are disclosed. The head comprises a handle body having a base configured to be coupled to the aerosol container, an outlet, a flexible tube housed within the handle body. The flexible tube is configured to provide fluid communication between the container exit of the aerosol container and the outlet. And the head further comprises an elastically deformable actuator having a lever arm, and a coupling portion integrally formed with the lever arm and configured to be mounted around the flexible tube, wherein the coupling portion is further configured such that when the lever arm is deformed by a user, the coupling portion actuates on the valve body of the aerosol container. Aerosol containers having such heads and kits for treatments skin lesions are also disclosed.

Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and/or energy are effective to injury or damage the tissues to have a benefit of symptom relive.

Present disclosure provides a cooling device with safety features and methods for controlling temperature of the cooling device for safe cooling of target surface.