The invention relates to a system for assisting in planning a focal therapy treatment of a structure (1) within a patient body (2) by applying a treatment quantity using one or more devices (4a,b,c) operated in one or more device positions. The system comprises a unit (10) configured to generate a constraint function representing clinical objectives relating to the treatment quantity, a selection unit (11) configured to determine, for each of at least some non-selected candidate device positions, a sum of negative derivatives of the constraint function with respect to the treatment parameter associated with the respective device position and to select a device position for use in the treatment based on a comparison of the determined sums, and an optimization unit (12; 408) configured to determine at least one optimized treatment parameter for the selected device position based on the constraint function.

Embodiments include cryogenic systems and methods for treating pain or spasm associated with a nerve of a patient. A target nerve may be located and a distal end of a cryogenic system needle may be inserted into a tissue at a desired location in proximity to the target nerve. The needle includes an outer lumen and an inner lumen extending distally within the outer lumen, the inner lumen including a distal opening that is open to the outer lumen. A cooling fluid may be delivered from a cooling fluid source to the needle via a fluidic pathway, the fluidic pathway including the cooling fluid source, the inner lumen, and the outer lumen, wherein a flow of the cooling fluid cools the needle so that the needle cools the target nerve at the desired location sufficiently such that the pain or spasm is inhibited.

Disclosed is an adjustable cryoablation needle, comprising a needle rod (3), a front-segment heat-insulated tube (1), a rear-segment heat-insulated tube (2), and an gas inlet structure (7) penetrating the needle rod (3) and the front-segment heat-insulated tube (1), wherein the needle rod (3) can move relative to the rear-segment heat-insulated tube (2) in the axial direction of the rear-segment heat-insulated tube (2) so as to adjust a first axial distance between the front end of the rear-segment heat-insulated tube (2) and the front end of the needle rod (3); and the front-segment heat-insulated tube (1) can move relative to the rear-segment heat-insulated tube (2) in the axial direction of the rear-segment heat-insulated tube (2) The adjustable cryoablation needle can prevent the inconvenience caused by a doctor selecting the model of the cryoablation needle.

A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on cornea of an eye, in which the miniaturized needles penetrates into the eye; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect.

A device for treatment of acne includes: a case having a contact surface portion to contact a skin of an acne region, the contact surface portion being provided with at least one through hole; at least one needle inserted into the skin of the acne region through the through hole with the contact surface portion arranged in contact with the skin; a driving unit arranged inside the case; a needle fixing part arranged inside the case so as to fix the at least one needle and configured to be linearly moved by the driving unit; and a needle cooling unit configured to cooling the at least one needle to transfer coldness into the skin of the acne region through the at least one needle to suppress a function of a sebaceous gland in the skin of the acne region such that proliferation of propionibacterium acnes is limited.

The disclosure describes a cryogenic device with a display device for displaying one of a plurality of user-interfaces associated with a plurality of cryogenic device states. The cryogenic device is configured to: generate an initial user-interface for display on the display device; determine that the cryogenic device is in a first state; generate, in response to determining that the cryogenic device is in the first state, instructions for rendering a first user-interface, wherein the first user-interface is associated with the first state; and cause the display device to display the first user-interface. In this way, the cryogenic device may have a dynamic user interface that is configured to response to states of the cryogenic device.

In some embodiments, a method includes identifying a nerve extending across a transection path; administering a cooling therapy to the identified nerve at a location proximal to the transection path so as to degenerate the identified nerve across the transection path prior to or during surgical transection along the transection path, wherein cooling the identified nerve prevents or reduces neuroma formation at a transected end of the nerve after transection of the nerve. In some embodiments, a method includes degenerating a portion of a nerve while preserving a connective tissue framework of the nerve. During or after the degeneration, the preserved connective tissue framework may be transected at a transection location distal to the treatment location. The regeneration of the nerve may be repeatedly disrupted for a period of time to reduce a regenerative rate of the nerve and delay neuroma formation.

Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

An apparatus and method for sending test signals to an instrument, and checking the resultant and subsequently arriving echo signals in order to detect specific properties and changes of properties on the line, the instrument, the tissue or also on a fluid body, e.g., plasma body, present on an electrode of the instrument, and to control the operation of the supply arrangement accordingly.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and/or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.