Patent classifications
C07H17/07
NEW C-GLYCOSYLPOLYPHENOL ANTIDIABETIC AGENTS, EFFECT ON GLUCOSE TOLERANCE AND INTERACTION WITH BETA-AMYLOID. THERAPEUTIC APPLICATIONS OF THE SYNTHESIZED AGENT(S) AND OF GENISTA TENERA ETHYL ACETATE EXTRACTS CONTAINING SOME OF THOSE AGENTS
- Amélia Pilar GRASES SANTOS SILVA RAUTER ,
- Ana Rita Xavier De Jesus ,
- Alice Isabel Mendes Martins ,
- Catarina Alexandra Dos Santos Dias ,
- Rogério José TAVARES RIBEIRO ,
- Maria Paula BORGES DE LEMOS MACEDO ,
- Jorge Alberto Guerra Justino ,
- Helder Dias Mota Filipe ,
- Rui Manuel AMARO PINTO ,
- Bruno Miguel Nogueira Sepodes ,
- Margarida Alexandra PATRÍCIO GOULART DE MEDEIROS ,
- Jesus JIMENÉZ BARBERO ,
- Cristina Airoldi ,
- Francesco NICOTRA
The present invention concerns the antidiabetic activity of compounds type A, namely of 8-β-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to β-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes.
The inhibitory activity of β-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphastase by these two extracts and the diethyl ether plant extract is also part of the present invention.
Rutin-rich extract and method of making same
A method of obtaining a rutin-rich extract from a plant and a rutin-rich extract of Uncaria elliptica thus obtained.
Rutin-rich extract and method of making same
A method of obtaining a rutin-rich extract from a plant and a rutin-rich extract of Uncaria elliptica thus obtained.
Composition for inhibiting liver function deterioration, containing citrus peel extract or narirutin as active ingredient, and method for extracting narirutin from citrus peel
The present invention relates to a pharmaceutical composition for treating liver diseases, containing a narirutin extract of citrus peel extract or narirutin as an active ingredient. The extract or narirutin decreases cholesterol levels and fat levels in liver tissue, and thus can be utilized as a composition or food for preventing and treating liver diseases. In addition, the present invention relates to a method for extracting narirutin from citrus peel, and a method for preparing citrus fermented milk using the same.
Composition for inhibiting liver function deterioration, containing citrus peel extract or narirutin as active ingredient, and method for extracting narirutin from citrus peel
The present invention relates to a pharmaceutical composition for treating liver diseases, containing a narirutin extract of citrus peel extract or narirutin as an active ingredient. The extract or narirutin decreases cholesterol levels and fat levels in liver tissue, and thus can be utilized as a composition or food for preventing and treating liver diseases. In addition, the present invention relates to a method for extracting narirutin from citrus peel, and a method for preparing citrus fermented milk using the same.
Glycosyl hesperetin and process for producing the same and uses thereof
The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.
Glycosyl hesperetin and process for producing the same and uses thereof
The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.
Anti-inflammatory composition including novel kaempferol-based compound derived from post-fermented tea
The present specification relates to an anti-inflammatory composition including a novel compound isolated from a post-fermented tea, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, and may be widely used in various areas related to anti-inflammation.
Anti-inflammatory composition including novel kaempferol-based compound derived from post-fermented tea
The present specification relates to an anti-inflammatory composition including a novel compound isolated from a post-fermented tea, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, and may be widely used in various areas related to anti-inflammation.
METHODS OF TREATING CANCER USING PLATANOSIDE AND ISOMERS THEREOF
This invention relates to methods of treating cancer with platanoside and/or isomers thereof or pharmaceutically acceptable salts thereof, particularly treatment of a pancreatic, liver or brain cancer. This invention further relates to methods of treating cancer with platanoside and/or isomers thereof, produced from Ephedra foeminea.