Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.

Described herein are methods for quantifying IAIP levels in a sample.

The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.

The present disclosure relates to cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance. In addition, the present disclosure relates to methods of making and using the cells, tissues, organs, and/or animals having one or more of the modified genes.

A protein comprising amino acid sequence of SEQ ID NO: 115, within which a segment of general formula Ih-mod GX.sub.1CX.sub.1VX.sub.2X.sub.3X.sub.4X.sub.5 is present where X.sub.1 is any of F, Y, L, P, Q, M, V, W, A, or T, X.sub.1V is R, or K, X.sub.2 is any of A, G, S, or T, X.sub.3 is any amino acid of the 17-set, where the 17-set comprises A, I, L, F, or Y, X.sub.4 is any of K, I, Q, R, H, S, F, M, N, L, or V, and X.sub.5 is any of R, V, I, K, M, Q, E, F, L, N, Y, D, S, H; and b) in position 34 of SEQ ID NO: 115 it contains an amino acid selected from the 34-set contains any amino acid of the 34-set, where the 34-set comprises Y, I, F, G, V and S, and use in pharmaceutical preparations, kits, screening procedures.