A compound is provided which is effectively adsorbed to a substrate surface, such as an immune reaction vessel, has extremely high protein adsorption inhibitory effect that inhibits non-specific adsorption of protein or the like, and has excellent washability to retain the inhibitory effect before and after washing operation of the substrate. Also provided are a protein adsorption inhibitor using the compound, a phosphorylcholine-modified substrate, and a method for inhibiting protein adsorption. The compound is a phosphorylcholine group-containing polyethylene glycol derivative represented by formula (1). The method for inhibiting protein adsorption of the present invention includes the step of forming an adsorbed layer of the derivative on a substrate surface. ##STR00001##

A polymer electrolyte including a poly(ethylene oxide) (PEO) containing polymer; and a lithium salt, wherein a terminal of the poly(ethylene oxide) containing polymer is substituted with a sulfur compound functional group, a nitrogen compound functional group or a phosphorus compound functional group, and a method for preparing the same and a battery containing the same.

The present invention relates to a multilayer structure including a base (X) and a layer (Y), wherein

the layer (Y) includes an aluminum-containing compound (A) and a phosphorus compound (BH) in which a phosphorus atom having at least one hydroxy group and a polar group are bonded via an alkylene chain having 3 to 20 carbon atoms or a polyoxyalkylene chain based on an alkylene having 3 to 20 carbon atoms, and

the aluminum-containing compound (A) is a compound (Ab) including a reaction product (D) of an aluminum-containing metal oxide (Aa) and an inorganic phosphorus compound (BI).

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

The invention relates to compositions containing compounds of formula (I), formula (II), or mixtures thereof, in which n is an integer greater than or equal to 1, R.sup.1, an aliphatic, linear or branched hydrocarbon group having 1 to 10 carbon atoms, a hydrogen atom, the structural unit —O—X, or the structural unit —CH.sub.2—O—X, X corresponds to formula (III), in which a is an integer from 2 to 6, b is an integer from 0 to 3, c is an integer from 20 to 28, m is 1 or 2, R.sup.2 is an aliphatic, linear or branched hydrocarbon group having 1 to 10 carbon atoms, Y is hydrogen, —SO.sub.3M, —SO.sub.2M, —PO.sub.3M.sub.2, or —CH.sub.2COOM, and M is a cation. The compounds of formula (I), of formula (II), or mixtures thereof are preferably suitable to act as a dispersing agent.

##STR00001##

The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of otitis media. Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.

Disclosed are novel phosphono-phosphate compounds, monomers, and polymer compositions that have targeted uses with divalent cations and surfaces having divalent cations. These compounds can be used to deliver actives to surfaces such as calcium hydroxyapatite.

The invention provides aqueous coating composition having freeze thaw stability, comprising: (a) at least one latex polymer derived from at least one monomer and at least one reactive surfactant of the formula
R.sub.1O(CH.sub.2CHR.sub.2O).sub.x(CH.sub.2CH.sub.2O).sub.y(CH.sub.2CHR.sub.3O).sub.zR.sub.4
where R.sub.1 is either alkyl, aryl, alkylaryl, or aralkylaryl of 8-30 carbon atoms, R.sub.2 is CH.sub.2OCH.sub.2CHCH.sub.2 (AGE); R.sub.3 is either H, CH.sub.3, or CH.sub.2CH.sub.3; R.sub.4 is H or SO3M or PO3M where M is H or K, Na, NH.sub.4, NR.sub.4, alkanolamine, or other cationic species and x=2-100; y=4-200 and z=0-50.

Disclosed are oral care compositions of novel phosphono-phosphate and anionic group containing polymer compositions that have targeted uses with divalent cations and surfaces having divalent cations. These compounds can be used to deliver anionic character to surfaces such as calcium hydroxyapatite for use in oral care applications.

A polymer electrolyte is provided, which includes a polymer including an ethylene oxide unit; and a lithium salt, wherein the terminal of the polymer is substituted with one to four functional groups selected from the group consisting of a nitrogen compound functional group and phosphorus compound functional group, and the terminal of the polymer and the one to four functional groups are linked by one selected from the group consisting of a C2 to C20 alkylene linker, a C2 to C20 ether linker, and a C2 to C20 amine linker. A method for preparing the same is also provided.