The present invention regards a sterile workspace with removable layers for use on medical surfaces such as anesthesia workstations, as well as other surfaces. The assembly of the present invention generally includes a plurality of sterile workspaces, layered to form the assembly. Each workspace has a foam layer and a barrier layer. In some configurations, the workspace also has a tray, and the foam layer is secured to the top surface of the tray. The tray may have a raised border about its perimeter. In some configurations the foam layer has a non-porous bottom surface. The assembly may have a support surface under the bottom-most workspace layer, with an elastomer or adhesive affixed thereto to prevent the assembly from moving during use. The barrier layer is affixed to either the foam layer, or the tray (if present), and is removed to expose a sterile workspace when in use.

A package system for a medical device is disclosed. The package system may include a first part and a second part, where a holding platform can be incorporated into the first part of the package system and a collection tray can be incorporated into the second part of the package system. The first part may include leg portions. The leg portions of the first part can be folded and fitted into matching pockets of the second part, so that the first part of the package system can provided a relatively elevated and stable holding platform to hold the medical device. The package system can contain the medical device in the package system in a storage state, and hold the medical device with the holding platform in an application state.

A system for packaging a kit for a radiofrequency ablation procedure protects a radiofrequency ablation kit without compromising its sterile barrier system through the hazards of handling, distribution, and storage. The system includes: an introducer tray configured to hold at least one introducer; a probe tray configured to hold at least one radiofrequency ablation probe; an outer carrier tray, a pouch configured to hold a tubing kit; and a dispenser carton. The introducer tray and the probe tray are held within the outer carrier tray, and the outer carrier tray and the pouch are configured to be held within the dispenser carton. A method of packaging a radiofrequency ablation kit is further described.

In an aspect, a method of manufacturing a surgical kit includes providing one or more medical devices based on a three-dimensional (3D) image of an anatomical structure. The method additionally includes providing packaging based on the 3D image, and providing the surgical kit utilizing the packaging and the one or more medical devices. In another aspect, a surgical kit has one or more contoured packaging surface having a contour that matches a contour of an anatomical structure. The contoured packaging surface has one or more features for receiving one or more medical devices provided based on the contour in the 3D image. The surgical kit additionally has a lid connected under pressure with the one or more contoured packaging surface. The lid has apertures for sterilization of components of the one or more medical devices situated between the lid and the contoured packaging surface.

The present invention provides isolated monoclonal antibodies that specifically bind to Sialyl Lewis A (SLeA) glycan, fragments thereof and humanized version of said antibodies or fragments, as well as conjugates thereof. The invention further provides chimeric antigen receptors comprising said antibodies or fragments and cells, such as T cells comprising same. The invention further provides pharmaceutical compositions comprising all of the above agents and use of said agents and compositions for diagnosing and treating cancer characterized by overexpression of SLeA.

A liner for an endoscope storage tray is provided. The liner has an interior comprising a flexibly deformable material substantially impermeable to fluids and an absorbent material disposed within or attached to at least a portion of the flexibly deformable material. The liner is configured to temporarily line at least an interior of the endoscope storage tray. Systems and methods are also provided.

A surgical kit includes a surgical instrument, a packaging, and a return packaging. The packaging defines an interior and an exterior in a closed configuration. The surgical instrument is disposed within the interior of the packaging or coupled with the packaging in the closed configuration. The packaging is configured to transition to an open configuration by a user to expose the interior and allow for access of the surgical instrument during a surgical procedure. The return packaging is configured to receive at least a portion of the surgical instrument after the surgical procedure for reduced cross-contamination. The return packaging is at least one of coupled with the packaging or disposed within the interior in the closed configuration.

An aspect of the present disclosure is a tray for containing a medical device during a sterilization process. The tray includes a bottom portion comprising a plurality of perforations extending through a surface of the bottom portion. The tray further includes a plurality of side portions extending from the bottom portion, the plurality of side portions each comprising a plurality of slots extending through a surface of each respective side portion. The tray further includes a cover configured to releasably engage the plurality of side portions, the cover comprising a plurality of openings extending through a surface of the cover. Trays disclosed herein are designed to minimize residual liquid leakage and freezing and maximize diffusion of sterilant through the tray and into contact with the medical device(s).

The present disclosure describes a container that includes a body having a lower surface, an upper rim, and a plurality of side walls that extend between the lower surface and the upper rim, wherein the upper rim defines an opening to an interior space of the body, a flexible cover that covers the opening of the body and is bonded to the body along the upper rim, and gas-permeable material through which gas can enter and exit the interior space of the body. The upper rim of the body is spaced apart from any of the gas-permeable material, such that the cover can be peeled away from the upper rim to expose the opening while leaving the gas-permeable material intact.

In an aspect, a method of manufacturing a surgical kit includes providing one or more medical devices based on a three-dimensional (3D) image of an anatomical structure. The method additionally includes providing packaging based on the 3D image, and providing the surgical kit utilizing the packaging and the one or more medical devices. In another aspect, a surgical kit has one or more contoured packaging surface having a contour that matches a contour of an anatomical structure. The contoured packaging surface has one or more features for receiving one or more medical devices provided based on the contour in the 3D image. The surgical kit additionally has a lid connected under pressure with the one or more contoured packaging surface. The lid has apertures for sterilization of components of the one or more medical devices situated between the lid and the contoured packaging surface.