Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

An OCT (Optical Coherence Tomography) handheld device is provided comprising: a housing configured for handheld OCT scanning during a surgical procedure, the housing comprising an OCT scanning end and a proximal end opposite the OCT scanning end; an OCT scanning device inside the housing, the OCT scanning device configured for one or more of OCT polarized scanning and Doppler OCT scanning from the OCT scanning end, the OCT scanning device further configured to receive and convey OCT light between the proximal end and an OCT analysing system; and a tip extending from the OCT scanning end, the tip being removably attached to the OCT scanning end, the tip configured to receive and collect the OCT light therethrough. The OCT handheld device is configured to be removably draped around the tip, for use in the surgical procedure.

Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.

An evaluation system including a hardware system for collecting real-time data for evaluating sleeping comfort performance of a bedding system is disclosed. The hardware system includes a thermal and moisture comfort measurement system, a thermal and moisture comfort control system, a biomechanical comfort control system, and a biomechanical comfort measurement system. The evaluation system also includes a computational system having a processor and a tactile database, and a portable device. The computational system is configured to receive and process the real-time data from the hardware system, and is communicatively connected to the portable device for transmitting real-time data for evaluating the bedding system and adjusting the hardware system. A mobile application executable on the portable device is configured to collect subjective opinion of the sleeper using questionnaires, and the processor is configured to perform combined analysis of the subjective opinion and the real-time data of the bedding system.

In one embodiment, a personal care implement is disclosed. The personal care implement has an emitting end and an electromagnetic source for projecting electromagnetic radiation onto an area of skin to treat a skin condition. A light sensor is configured to sense an amount of ambient light present at the emitting end. A controller instructs the electromagnetic source to begin projecting only when the light sensor senses that the amount of ambient light at the emitting end is below a predefined threshold.

An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.

Systems, methods, and devices for securing a spinal rod are provided. A clamp assembly comprises a tulip comprising an opening comprising an inner surface, wherein the inner surface is threaded; and a threaded locking cap disposed in the opening, wherein threads of the locking cap and the inner surface include various geometries.

A probe for detecting cancerous tissue, the probe including an illuminator, an optical spectrum analyzer, and an indicator for indicating whether cancerous tissue has been detected in reflected spectrum analyzed by the optical spectrum analyzer. A method for detecting cancerous tissue, the method including providing a probe including an optical spectrum analyzer, placing the probe to include tissue-to-be-tested within a Field-Of-View (FOV) of the spectrum analyzer, optically illuminating the tissue-to-be-tested, analyzing light reflected from the tissue-to-be-tested, and determining whether or not cancerous tissue is detected in the FOV. Related apparatus and methods are also described.

Techniques are described for non-invasive, cuff-less measurement of blood pressure of a user using a portable electronic device. Illumination is projected through a body part and received by photodetectors on the other side of the body part. The body part includes elastic pathways of the circulatory system through which blood flows. Cycles of contraction and relaxation by the heart cause pulse waves to travel through the blood, which cause volumetric changes in the elastic pathways. The transient changes in blood volume result in corresponding transient changes in the amount of illumination that is absorbed by the body part versus the amount that passes through to the photodetectors, as manifest by a detection output signal. Calibration data can be used to convert the detection output signal to blood pressure measurements, such as including diastolic and systolic blood pressure readings.

A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak.