An intracranial implant to position a fiber bundle to a specified region of a brain of an animal. The implant may include a base support to be fixed to a skull of the animal over an orifice drilled in the skull, a hollow conduit arranged through the base support to guide the fiber bundle to the brain of the animal through the drilled orifice and a first locking member arranged on the base support, to cooperate with a ferrule of the fiber bundle, the first locking member configured to lock the fiber bundle to the specified region of the brain of the animal.

Exemplary pre-operative electrode-dispensing neuromonitoring gun systems and methods involve the administration of a neuromonitoring electrode to a patient. A system can include a dispensing device and a cartridge. The dispensing device can have a case, a trigger, and a pusher. The cartridge can have a plurality of electrodes. In some cases, an electrode can include two subdermal leads, a posterior connection port or plug, and a casing to house the connection port before placement and to cover the leads upon removal.

Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Various examples are described for needle alignment for wearable biosensors. One example device includes a housing comprising an upper portion and a lower portion, the housing defining a cavity between the upper portion and the lower portion and configured to be worn on a wearer's skin, wherein: the upper portion defines a first opening extending through the upper portion to the cavity, and the lower portion defines a second opening extending through the lower portion to the cavity, the cavity establishing a substantially unobstructed pathway including the first opening and the second opening to enable an insertion needle to be inserted through the housing; and a needle guide extending into and along a portion of the pathway and aligned with a sensor wire to enable alignment between the insertion needle and the sensor wire.

A miniaturized sensing probe and a manufacturing method thereof are provided. The miniaturized sensing probe includes: a probe substrate including a probe part and a circuit connection part; a sensor disposed on the probe part and electrically connected to the circuit connection part; and a needle unit used to accommodate the probe part of the probe substrate; wherein the sensor performs sensing when placed into an analyte through the needle unit and transmits a sensing signal through the circuit connection part. The miniaturized sensing probe of the present invention may be easily placed into the analyte without the use of other instrument or surgery. This means is of benefit to a clinician performing an early diagnosis on a patient with a peripheral vascular disease or monitoring the biological value of the muscle during surgery in real time.

The subject invention pertains to a novel system capable of long-term monitoring the concentration of a typical analyte in body fluid. The invention includes an untethered battery-free concentration monitor and an external data recorder to continuously measure the concentration of certain analytes and send out signals corresponding to the measured analytes concentration in real-time.

An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices. Embodiments include removing a substantially cylindrical cap from an inserter to expose a substantially cylindrical sleeve, removing a cover from a substantially cylindrical container holding sensor components, and fitting the sensor components into the inserter.

A system for analyzing a patient using a transcutaneous sensor, having a base unit for attaching to the patient, an injector, releasably connectable to the base unit, for the transcutaneous insertion of the sensor into the patient, and a detection unit, releasably connectable to the base unit, for generating measurement data by the sensor. The base unit has a holding device which is configured to cooperate with the injector and detection unit such that, in a detection configuration with the detection unit arranged on the base unit, a contact pressure is applied to the sensor by the holding device for frictional fixing, and in an injection configuration with the injector arranged on the base unit, a lower contact pressure than in the detection configuration is applied to the sensor by the holding device.

The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.

At least one embodiment is directed to a tracking system for the muscular-skeletal system. The tracking system can identify position and orientation. The tracking system can be attached to a device or integrated into a device. In one embodiment, the tracking system couples to a handheld tool. The handheld tool with the tracking system and one or more sensors can be used to generate tracking data of the tool location and trajectory while measuring parameters of the muscular-skeletal system at an identified location. The tracking system can be used in conjunction with a second tool to guide the second tool to the identified location of the first tool. The tracking system can guide the second tool along the same trajectory as the first tool. For example, the second tool can be used to install a prosthetic component at a predetermined location and a predetermined orientation. The tracking system can track hand movements of a surgeon holding the handheld tool within 1 millimeter over a path less than 5 meters.