Disclosed are devices, systems and methods for in vivo monitoring of localized environment conditions within a patient user by measuring analytes, including glucose, oxygen, and/or other analytes. In some aspects, a sensor device includes a wafer-based substrate, at least one electrochemical sensor two-electrode contingent including a working electrode and a reference electrode on the substrate and configured to detect a target analyte in a body fluid when the sensor device is deployed within a subject's body, where the working electrode is functionalized by a chemical layer configured to facilitate a reaction involving the target analyte that produces an electrical signal; and an electronics unit in communication with the electrochemical sensor electrode contingent to transmit the electrical signal to an external processor.

A dry electrode and a physiological multi-parameter monitoring equipment are disclosed. The waterproof dry electrode comprises an encapsulation, extraction electrode and a contact surface layer, wherein the extraction electrode and the contact surface layer are connected with each other and disposed in the encapsulation; the contact surface layer comprises an exposed part and an embedded part encapsulation; the encapsulation comprises flexible silica gel and hard plastic portion, the embedded part being embedded into the hard plastic portion, and the hard plastic portion being packaged in the flexible silica gel. Through the above arrangement in the present invention, the dry electrode can reach a waterproof grade of IPX7, which is higher than living waterproof grade of an ordinary dry electrode. The PMPME can be a patch-type acquisition and monitoring equipment which is convenient for long time wearing and physiological multi-parameter monitoring, with excellent sealing and waterproofness, and the electrode is reusable.

A flexible sensor is provided which has a flexible substrate of polymeric material, a bottom electrode layer arranged on the flexible substrate and configured to be a reference electrode, an active layer of piezoelectric material arranged on the bottom electrode layer, a top electrode layer arranged on the active layer and configured to be connected to a signal conductor, and a flexible coating layer of polymeric material that cooperates with the flexible substrate to encapsulate the bottom electrode layer, the active layer, and the top electrode layer. The flexible sensor has an additional layer of metal material arranged on the flexible coating layer and short-circuited to the bottom electrode layer, the additional layer and the bottom electrode layer acting as an electromagnetic shield for the flexible sensor.

The present invention relates to a syringe-injection-type brain signal measurement and stimulation structure, and a syringe injection method therefor, and provides a structure including a high-performance flexible element capable of minimizing a skull opening when inserted into the brain. Particularly, the present invention comprises: a flexible element, which includes a contact part making contact with a surface of a cortex so as to measure a signal generated in the brain or transmit an external stimulus to the brain, a transmitting/receiving part positioned between a skull and a skin, and a connection part for making a connection between the contact part and the transmitting/receiving part; and an integrated circuit connected to the transmitting/receiving part so as to transmit/receive a signal.

A device for skin-contact biological measurement includes one or more electrodes to enable signal transmission through a skin contact and a control mechanism coupled to the one or more electrodes to adjust an electrode-to-skin impedance (ESI). The control mechanism is configured to implement the ESI adjustment using a thermal actuator.

Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.

The subject of this disclosure is devices, systems, and uses thereof to treat a plurality of patients for paroxysmal atrial fibrillation. The solution can include delivering a multi-electrode radiofrequency balloon catheter and a multi-electrode diagnostic catheter to one or more targeted pulmonary veins; ablating tissue of the one or more targeted pulmonary veins using the multi-electrode radiofrequency balloon catheter; diagnosing the one or more targeted pulmonary veins using the multi-electrode diagnostic catheter; and achieving at least one of a predetermined clinical effectiveness and acute effectiveness of the method or use based on use of the multi-electrode radiofrequency balloon catheter and the multi-electrode diagnostic catheter in the isolation of the one or more targeted pulmonary veins.

Transducer-based systems and methods may be configured to display a graphical representation of a transducer-based device, the graphical representation including graphical elements corresponding to transducers of the transducer-based device, and also including between graphical elements respectively associated with a set of the transducers and respectively associated with a region of space between the transducers of the transducer-based device. Selection of graphical elements and/or between graphical elements can cause activation of the set of transducers associated with the selected elements. Transducer activation characteristics, such as initiation time, activation duration, activation sequence, and energy delivery characteristics, can vary based on numerous factors. Visual characteristics of graphical elements and between graphical elements can change based on an activation-status of the corresponding transducers. Activation requests for a set of transducers can be denied if it is determined that a transducer in the set of transducers is unacceptable for activation.

A proto-microelectrode, a proto-microelectrode bundle and array, a method of manufacture of the proto-microelectrode, and a method of using the proto-microelectrode, the proto-microelectrode being capable of forming a microelectrode upon implantation into soft tissue, and includes an oblong electrode body; an optional first coat of electrically non-conducting material on the electrode body; a second coat of water insoluble flexible polymer material enclosing, at a distance, the electrode body and the first coat, the second coat including one or more through openings; a first layer of ice disposed between the electrode body and the second coat.

Disclosed are various examples and embodiments of a Nitinol basket for an electrophysiological (EP) mapping catheter. In one embodiment, the Nitinol basket comprises a plurality of basket splines, each basket spline having a distalmost portion and a proximal end, where the distal tip is uninterruptedly contiguous and continuous with the distalmost portions of the basket splines and formed from the same piece, slab or ingot comprising Nitinol as the splines. In such an embodiment, the basket splines and distal tip are cut and formed from a same single length or piece of Nitinol tubing or a Nitinol hypotube. The respective distal portions of each of the Nitinol splines can be continuous and contiguous with, and connected to, the Nitinol distal tip, each spline being configured to extend outwardly away from an imaginary central axis of the Nitinol basket and its proximal end and distal portion to form a curved shape therebetween when the Nitinol basket is in an undeformed and deployed state. The splines can be configured to be spaced approximately equal distances apart from one another when the Nitinol basket is in an undeformed and deployed state, and the can be configured collectively to form a basket shape when the Nitinol basket is in an undeformed, expanded and deployed state.