The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.

The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.

The present invention provides a -agarase, a composition containing the same and applications thereof. The present -agarase provides the field a novel alternative and is favorable for the industrial utilities of the hydrolysis products of agarose. Furthermore, the hydrolysis product of agarose by the present -agarase has high purity of neoagarotetraose therefore the present -agarase is especially useful for the neoagarotetraose's utilities in the field.

The invention provides protein particles having improved whiteness after storage, and powder detergents comprising the particles.

Provided is a lactase preparation having an excellent lactose decomposing action in milk. A lactase according to an aspect of the present invention has, as lactase activity, any one of the following activities (1) to (6) or a combination of two or more thereof: (1) when the lactase is added to cow's milk, an added amount of protein in the lactase at which a residual lactose concentration reaches 0.1% or less after 16 hours at 10 C. is 15.1 mg/L or less; (2) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.01% or less after 16 hours at 10 C. is 30.2 mg/L or less; (3) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.10% or less after 24 hours at 10 C. is 10.1 mg/L or less; (4) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.01% or less after 24 hours at 10 C. is 15.1 mg/L or less; (5) when the lactase is added to cow's milk in an amount that makes a final concentration 1.4 LYU/ml, the residual lactose concentration reaches 0.1% or less after 24 hours at 10 C.; and (6) when the lactase is added to cow's milk in the amount that makes a final concentration 2.1 LYU/ml, the residual lactose concentration reaches 0.01% or less after 24 hours at 10 C.

The present invention provides a -agarase, a composition containing the same and applications thereof. The present -agarase provides the field a novel alternative and is favorable for the industrial utilities of the hydrolysis products of agarose. Furthermore, the hydrolysis product of agarose by the present -agarase has high purity of neoagarotetraose therefore the present -agarase is especially useful for the neoagarotetraose's utilities in the field.

The invention provides an aqueous liquid lactase formulation comprising lactase and further comprising sodium, calcium or potassium-L-lactate or a combination thereof and optionally a sugar, and/or optionally comprising sodium or potassium chloride or a combination thereof, preferably wherein the concentration of each of the components is such that the water activity A.sub.w is at most 0.82. The formulation is particularly suitable when using invertase-free lactase, allowing the use of sucrose as stabilizer. The invention also provides a process to produce the liquid lactase formulation of the invention, an infant formula (e.g. as powder of granulate) comprising the liquid lactase formulation of the invention, a method to produce said infant formula, and the use of the formulation in the production of infant formula.

A lactase preparation includes lactase and has a lactase activity of 4,000 NLU/g or more according to the FCC IV method, wherein the lactase originates from a lactase gene of yeast, and wherein the lactase preparation has an arylsulfatase activity of 0.1% or less based on the lactase activity, in which the arylsulfatase activity (unit: U/g) is determined and calculated.

An object of the present invention is to provide a lactase solution showing good permeation through a filtration filter, a lactase solution showing good permeation through a filtration filter and having a good residual lactase activity, and a lactase solution showing good permeation through a filtration filter and having a good residual lactase activity even when a lactase solution having a low protease activity and a low arylsulfatase activity as contaminant enzymes is used.

A lactase solution containing any of (i) to (iii) below. (i) 0.0001 to 0.1 mass % of an unsaturated fatty acid or a salt thereof (ii) 0.0001 to 0.1 mass % of a saturated fatty acid salt (iii) 0.01 to 10 mass % of at least one selected from yeast extract, soybean peptone, pea protein, a casein degradation product, and corn steep liquor

The present invention relates to a sterile-filtered liquid lactase preparation and to a method of sterile filtering a liquid lactase preparation.