The present invention relates to medical nanobots with embedded biosensors for real-time and continuous in-vivo anatomic localization, diagnosis, disease surveillance, and therapeutic intervention.

An analysis method is provided which includes providing nanodiamond in a vicinity of a sample; and measuring a content of a compound having a near infrared absorption peak amplified by the nanodiamond in the sample using near infrared spectroscopy. Also, a near infrared spectroscopy sensor is provided which includes a near infrared spectroscopy sensor main body including a layer containing nanodiamond on a surface that receives near infrared rays of the near infrared spectroscopy sensor main body.

Provided is a biosignal acquiring tool, including: a textile structure in which a non-slip textile is disposed; an electrode positioned on a surface of the textile structure; a connector configured to connect an electronic device configured to acquire a signal from the electrode; and an elastic belt capable of being stretched independently of the textile structure. The elastic belt is disposed in parallel with the textile structure, while facing a surface of the textile structure that is different from the surface on which the electrode is positioned. The elastic belt is coupled to the textile structure at a portion different from a portion at which the electrode is positioned and at a portion different from surroundings of the portion. The textile structure is capable of being displaced within a range of 2 mm or more and 10 mm or less in the width direction of the elastic belt.

Disclosed is a method of forming a conductive diamond layer on a surface of a carbon fibre substrate that is used as a component of an electrode for neural stimulation and/or electrochemical sensing. The method comprises functionalising at least a portion of the surface with a functionalising agent to facilitate coating the surface with the conductive diamond layer. The method also comprises providing a diamond precursor and depositing the diamond precursor over the functionalising agent to form the conductive diamond layer. The disclosure also relates to an electrode that is used as a component of an electrode for neural stimulation and/or electrochemical sensing.

This application features a method of forming a nanoporous layer. The method includes steps of dispensing on a substrate a colloid composition comprising a liquid and a number of nanoparticle clusters, and subjecting the dispensed colloid composition to drying to form the nanoporous layer over the substrate. The nanoporous layer includes nanoparticles deposited to form a three dimensional network of irregularly shaped bodies. The nanoporous layer also includes a three dimensional network of irregularly shaped spaces that are not occupied by the three dimensional network of irregularly shaped bodies.

A method is presented for forming a nanowire electrode. The method includes forming a plurality of nanowires over a first substrate, depositing a conducting layer over the plurality of nanowires, forming solder bumps and electrical interconnections over a second flexible substrate, and integrating nanowire electrode arrays to the second flexible substrate. The plurality of nanowires are silicon (Si) nanowires, the Si nanowires used as probes to penetrate skin of a subject to achieve electrical biopotential signals. The plurality of nanowires are formed over the first substrate by metal-assisted chemical etching.

A sensing and treatment device includes an array of metal nanorod electrodes formed on a substrate, the array including first electrodes for sensing, and second electrodes for electrical pulsation. A data processing system is configured to monitor a parameter using the first electrodes and to activate the electrical pulsation in the second electrodes in accordance with a reading of the parameter.

A device for detection of tetrahydrocannabinol or THC in a sample includes a sensor including a substrate and a sensor medium on the substrate. The sensor medium includes at least one nanostructure, wherein at least one property of the sensor medium is dependent upon the presence of THC on a surface of the sensor medium. The device further includes electronic circuitry including at least one measurement system in operative connection with the sensor to measure a variable relatable to the at least one property of the sensor medium dependent upon the presence of THC.

The present disclosure relates to a nanosensor for real-time monitoring of wound healing, a manufacturing method thereof, and a real-time monitoring system for wound healing using the same. A nanosensor according to example embodiments includes a biomarker for detecting mRNA and a reference gene on gold nanoparticles, thereby providing an objective indicator through monitoring of wound healing, enabling monitoring of wound healing through direct monitoring using real-time fluorescence by including a fluorescent marker in a nanoflare, and enabling evaluation of a whole wound healing process in normal and patient groups (diabetes) through real-time monitoring. In addition, the nanosensor according to the example embodiments has advantages of shortening synthesis time and improving efficiency by 30% through integration of a novel synthesis method (freezing method) rather than an existing synthesis method (salt aging).

Methods and systems for stimulating and monitoring electrogenic cells are described. Some systems for stimulating electrogenic cells are based on the injection of electric currents into the cells via electrodes connected to the cells. Such stimulators may comprise an impedance element having an input terminal and an output terminal coupled to an electrode, and a voltage follower coupled between the input terminal and the output terminal of the impedance element, the voltage follower being configured to maintain a substantially constant voltage between the input terminal and the output terminal of the impedance element. The impedance element may comprise one or more switched capacitors at least in some embodiments. In some embodiments, the voltage follower may be implemented using a source follower.