During both invasive and non-invasive treatments and therapies, inaccuracies in locating the areas of interest mean that not all the area is treated, or the treatment is incomplete. A magnetic field probe 100, 101, 102, 103 is provided that improves determination of a disposition of an implantable magnetic marker 200, the probe comprising a first 110, 120 and second 110, 120 magnetic sensor, substantially disposed along a transverse axis intersecting the longitudinal axis of the probe 150. The first 110, 120 and second 110, 120 magnetic sensors are close to the distal end 160 of the probe, and are separated by a minor sensor separation. A third 120, 130 magnetic sensor is provided close to the proximal end 165, separated by a major sensor separation from the second magnetic sensor 110, 120 close to the distal end 160, the major sensor separation being larger than the minor sensor separation; and the ratio of the major sensor separation to the minor sensor separation is in the range 1.25 to 40, preferably in the range 1.6 to 7.6.

In this example, the second magnetic sensor is functionally configured and arranged to co-operate with both the first magnetic sensor and the third magnetic sensor. This may be implemented using three or more magnetic sensors.

This provides a probe capable of accurately determining one or more dispositions of the implantable magnetic marker when the distal end of the probe is close to the marker and also when it is further away.

In particular, including the pair of sensors close to the distal end may increase the sensitivity and accuracy of the probe.

An integrated closed-loop artificial pancreas includes: a detection module; a program module which is imported into the total daily dose algorithm and the current insulin infusion algorithm; and an infusion module which is connected to the program module. The infusion module includes an infusion tube which is used as the insulin infusion channel, the detecting electrodes are provided on/in the wall of the infusion tube, and the infusion module can infuse insulin required according to the data of the current insulin infusion dose. It takes only one insertion to perform both glucose detection and insulin infusion.

A method for adjusting an output signal of a pulse diagnosis device includes obtaining a pulse signal at a pulse diagnosis region that is acquired by a sensing element of the pulse diagnosis device, and performing a parameter recognition on the pulse signal to obtain a parameter of the pulse signal, and determining a biological structure of the pulse diagnosis region based on the parameter of the pulse signal. The method also includes determining an adjustment factor for the parameter of the pulse signal based on the biological structure, and adjusting the parameter of the pulse signal based on the adjustment factor for the parameter of the pulse signal, to obtain an adjusted pulse signal for the pulse diagnosis region. The pulse signal is a pressure signal applied by an artery in the pulse diagnosis region to an external skin surface corresponding to the artery.

Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.

A wearable device according to an embodiment includes a detection unit, a first layer, a second layer, and a third layer. The detection unit detects the living body information. The first layer is flexible and disposed in a first direction relative to the detection unit and includes a conductor electrically connected to the detection unit. The second layer is disposed in the first direction relative to the first layer and is harder than the first layer. The third layer is disposed in the first direction relative to the second layer and includes an electronic component electrically connected to the conductor.

The electrocardiogram measurement apparatus includes: two amplifiers for receiving electrocardiogram signals from a first electrode and a second electrode; one electrode driving unit; a third electrode for receiving an output of the electrode driving unit; an A/D converter connected to an output terminal of each of the two amplifiers and converting analog signals into digital signals; a microcontroller for receiving the digital signals from the A/D converter; and a communication means for transmitting the digital signal, wherein: the microcontroller is supplied with power from a battery; the microcontroller controls the A/D converter and the communication means; and each of the two amplifiers amplifies one electrocardiogram signal so as to simultaneously measure two electrocardiogram signals.

A wearable device configured to secure to skin of a user and noninvasively measure body temperature of the user can include first and second pairs of temperature sensors configured to generate one or more signals responsive to detected thermal energy, a thermally conductive element positioned at least partially between the second pair of temperature sensors, and one or more hardware processors configured to receive the one or more signals generated by each of said first and second pairs of temperature sensors and determine one or more body temperature values of the user based on at least comparisons between different ones of the first and second pairs of temperature sensors. In some implementations, the wearable device includes thermally conductive probes for transmitting thermal energy toward ones of the first and second pairs of temperature sensors and a substrate positioned between the probes and the skin.

The distal end of the catheter can be constructed to include one or more features to provide strain relief to wiring of multiple single axis sensors. In some examples, the multiple single axis sensors and associated wiring can be manufactured over a flexible tube that can be placed over a movable support member. In some examples, wiring can be wound an increased number of consecutive traverse turns on a distal and/or proximal side of a single axis sensor, and a shrink sleeve may be positioned over the traverse turns. In some examples a wire shield transition point can be positioned on a straight portion in a proximal direction to the distal portion of the catheter.

A component analyzing apparatus is provided. The component analyzing apparatus includes: an impedance measurer including: a plurality of electrodes having an electrode width that is determined based on an effective measurement depth for analyzing a component of an analyte and a gap between two electrodes among the plurality of electrodes, and an electrode controller configured to apply a first current to a first electrode and a second electrode among the plurality of electrodes and configured to measure impedance based on a voltage between a third electrode and a fourth electrode; and a processor configured to analyze the component of the analyte based on the impedance measured by the electrode controller.

This invention is a wearable ring of optical biometric sensors comprising an arcuate array of light emitters and light receivers which is configured to collectively span at least half of the circumference of a person's wrist, finger, or arm. Light energy from the light emitters which has passed through the person's body tissue and/or has been reflected from the person's body tissue is analyzed in order to measure biometric parameters such as the person's oxygenation level, hydration level, glucose level, pulse rate, heart rate variability, and/or blood pressure.