C12N2795/14043

M13 BACTERIOPHAGE WITH A HIGH CYSTEINE CONTENT AND GENETICALLY ENGINEERABLE HYDROGELS

A genetically engineered bacteriophage that can be crosslinked to form a solid material, for example, a hydrogel.

Targeted genome modification using circular single-stranded DNA
12344858 · 2025-07-01 · ·

The present invention is directed to methods for generating one or more genetically modified cells by using a circular single stranded DNA (CiSSD) as a donor template and targeting genome modification. These methods include transferring one or more DNA polynucleotides into the cell for site-specific nuclease-mediated DNA repair and selecting one or more cells having the transferred DNA incorporated into the cell's genome.