An intraoral applicator device is described herein that is configured to transfer medicament from the applicator to the gums of a patient. The device and methods of use may assist in topically applying medicament e.g. a topical anaesthetic to the gums of a patient without the need for or use of needles or syringes. In one embodiment, the intraoral applicator device may comprise a body with a shape and configuration that generally conforms with at least part of the shape of the teeth and gums of a patient's oral cavity. The device further comprises a holder portion, the holder portion comprising a frame, the frame being configured to clamp over the teeth about a region of the patient's oral cavity such that, when fitted to the patient's oral cavity, at least a part of the holder portion is configured to be held between the patient's teeth when the patient bites their jaws together, the holder portion also gripping at least part of the body. Methods of delivering medicament to at least a portion of the gums of a patient in need thereof using the above device are also described.

An intraoral applicator device is described herein that is configured to transfer medicament from the applicator to the gums of a patient. The device and methods of use may assist in topically applying medicament e.g. a topical anaesthetic to the gums of a patient without the need for or use of needles or syringes. In one embodiment, the intraoral applicator device may comprise a body with a shape and configuration that generally conforms with at least part of the shape of the teeth and gums of a patient's oral cavity. The device further comprises a holder portion, the holder portion comprising a frame, the frame being configured to clamp over the teeth about a region of the patient's oral cavity such that, when fitted to the patient's oral cavity, at least a part of the holder portion is configured to be held between the patient's teeth when the patient bites their jaws together, the holder portion also gripping at least part of the body. Methods of delivering medicament to at least a portion of the gums of a patient in need thereof using the above device are also described.

The present invention concerns a novel use of therapeutic hydrogels in nonsurgical techniques to promote healing and regeneration of tissues whose structure and functions have been diminished due to chronic inflammatory disorders. More particularly, the invention provides therapeutic and regenerative hydrogel compositions and their nonsurgical delivery to periodontal treatment sites to treat periodontal and peri-implant diseases. Furthermore, the invention concerns a novel technique which involves the injection of said sterile therapeutic biomimetic hyaluronic acid hydrogel to which are tethered at least one host modulating agent, such as tetrahydrocurcuminoids, THC, and at least one additional tissue regenerative agent into the gingival connective tissue proper. The host modulating agent potentiates the periodontal tissue regeneration at the periodontal treatment site, while the biomimetic hyaluronic acid hydrogel serves in a dual capacity as a drug, a tissue regenerative agent carrier and as a biodegradable matrix around which the new connective tissue can regenerate. The invention also concerns oral care gel and paste compositions of at least one host modulating agent tethered to the HA tissue regenerative hydrogel formulated to be used in a synergistic home-based oral care regimen.

The present invention concerns a novel use of therapeutic hydrogels in nonsurgical techniques to promote healing and regeneration of tissues whose structure and functions have been diminished due to chronic inflammatory disorders. More particularly, the invention provides therapeutic and regenerative hydrogel compositions and their nonsurgical delivery to periodontal treatment sites to treat periodontal and peri-implant diseases. Furthermore, the invention concerns a novel technique which involves the injection of said sterile therapeutic biomimetic hyaluronic acid hydrogel to which are tethered at least one host modulating agent, such as tetrahydrocurcuminoids, THC, and at least one additional tissue regenerative agent into the gingival connective tissue proper. The host modulating agent potentiates the periodontal tissue regeneration at the periodontal treatment site, while the biomimetic hyaluronic acid hydrogel serves in a dual capacity as a drug, a tissue regenerative agent carrier and as a biodegradable matrix around which the new connective tissue can regenerate. The invention also concerns oral care gel and paste compositions of at least one host modulating agent tethered to the HA tissue regenerative hydrogel formulated to be used in a synergistic home-based oral care regimen.

The present invention provides a method of treating a condition affecting a tooth or periodontium in a subject, comprising administering to the subject's tooth or periodontium a composition comprising biocompatible magnetic, magnetizable, or magnetically responsive agents; and applying an external magnetic field, wherein the magnetic, magnetizable, or magnetically responsive agents migrate to a desired location in response to the externally applied magnetic field, thereby treating a condition affecting the tooth or periodontium in the subject.

The present invention provides a method of treating a condition affecting a tooth or periodontium in a subject, comprising administering to the subject's tooth or periodontium a composition comprising biocompatible magnetic, magnetizable, or magnetically responsive agents; and applying an external magnetic field, wherein the magnetic, magnetizable, or magnetically responsive agents migrate to a desired location in response to the externally applied magnetic field, thereby treating a condition affecting the tooth or periodontium in the subject.

The present disclosure relates to compositions, including, hydrogel compositions useful as topical analgesics including cannabinoids and anesthetics. The present disclosure also disclosure relates to compositions, including, hydrogel compositions useful as topical analgesics including cannabinoids and anesthetic as well as carboxymethyl cellulose, carrageenan and a cross-linking agent.

The present disclosure relates to compositions, including, hydrogel compositions useful as topical analgesics including cannabinoids and anesthetics. The present disclosure also disclosure relates to compositions, including, hydrogel compositions useful as topical analgesics including cannabinoids and anesthetic as well as carboxymethyl cellulose, carrageenan and a cross-linking agent.

The Dental Needle Vibration Device comprises a vibrator motor device that may be formed onto a disposable dental or surgical needle, or may be reversibly coupled to a self-aspirating syringe. The Dental Needle Vibration Device couples to the disposable dental needle or self-aspirating syringe so that vibration motion from the vibrator motor is transmitted to the needle, improving control over the needle during vibration. The device is formed onto a disposable dental or surgical needle so that it does not rotate about the needle or move along the barrel of the needle. The device is coupled onto a self-aspirating syringe so that it is proximate to the needle in a fixed position so that it does not rotate about the syringe or move along the barrel of the syringe.

The Dental Needle Vibration Device comprises a vibrator motor device that may be formed onto a disposable dental or surgical needle, or may be reversibly coupled to a self-aspirating syringe. The Dental Needle Vibration Device couples to the disposable dental needle or self-aspirating syringe so that vibration motion from the vibrator motor is transmitted to the needle, improving control over the needle during vibration. The device is formed onto a disposable dental or surgical needle so that it does not rotate about the needle or move along the barrel of the needle. The device is coupled onto a self-aspirating syringe so that it is proximate to the needle in a fixed position so that it does not rotate about the syringe or move along the barrel of the syringe.