A delivery device and implantable prosthesis for repairing a soft tissue defect such as an abdominal wall hernia. The delivery device includes a support body that is nested between a first and second layer of the prosthesis. The support body includes a zone of weakness to facilitate collapse of the nested delivery device and prosthesis. A handle extends from the support body and may be used to position the prosthesis as well as to cause the support body to move to a reduced configuration for removal of the support body from the prosthesis.

An optical implantable member (102) is provided. The optical implantable member (102) includes an optic (104). The optic (104) includes an anterior surface (108) and a posterior surface (110), an optical centre (112) and a peripheral edge (116). The optical implantable member (102) is configured to be placed within a capsular bag of the eye. The optic (104) of the optical implantable member (102) includes a barrier (202). The barrier (202) is formed by a protrusion (202) on the posterior surface (110) of the optic (104). The protrusion (202) is concentric to an optical axis (114) of the optic (104). An outer wall (204 or 208) of the protrusion (202) is between the peripheral edge (116) and the optical centre (112). The barrier (202) restricts epithelial cells from migrating towards a central region of the capsular bag.

An exemplary process includes determining a desired pore size, selecting an initial pore size greater than the target pore size, manufacturing a porous structure with the initial pore size, forging the porous structure to form a forged part having the desired pore size, and forming an orthopedic device from the forged part.

Embodiments of an implant for use in surgery are disclosed. The implant may include elastic polymer file made from a suitable biologically compatible polymer. The implant may also include a reinforcement element.

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.

The present invention relates to the field of implants. In particular, the present invention relates to an implant for tissue reconstruction which comprises a scaffold structure that includes a void system for the generation of prevascularized connective tissue with void spaces for cell and/or tissue transplantation. Moreover, the present invention relates to a method of manufacturing such an implant, to the internal architecture of such an implant, to a removal tool for mechanical removal of space-occupying structures from such an implant, to a kit comprising such an implant and such a removal tool, to a removal device for the removal of superparamagnetic or ferromagnetic space-occupying structures from such an implant, as well as to a guiding device for providing feedback to a surgeon during the procedure of introducing transplantation cells into the void spaces generated upon removal of space-occupying structures from such an implant.

In various embodiments, the present invention is directed to a degradable poly(ester urea) (PEU)-based adhesion barrier, particularly suitable for use in connection with surgical mesh repair in the treatment of hernias and other soft tissue injuries comprising an amino acid based poly(ester urea) backbone and one or more zwitterionic side chains connected to the amino acid based poly(ester urea) backbone through a sulfide bond. In some other embodiments, the present invention is directed to method of making the PEU-based adhesion barriers comprising: preparing an amino acid based PEU polymer or terpolymer having one or more allyl functional groups; preparing a thiol functionalized zwitterionic compound; and reacting the allyl functionalized PEU polymer or terpolymer with the thiol functionalized zwitterionic compound to form a degradable PEU-based adhesion barrier having an amino acid based PEU backbone having zwitterionic side chains.

A method of manufacturing a plastic stent according to an embodiment of the present invention includes a first process of cleaning a surface of the stent including a plastic material to perform pretreatment, a second process of plasma-treating the pretreated surface of the stent, and a third process of introducing a hydrophilic functional group to the plasma-pretreated surface of the stent.

An implantable containment apparatus for receiving and retaining a plurality of cells for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a chamber having structural spacers therein to maintain an average distance between the first interior surface and the second interior surface of the chamber and to define at least one reservoir space for the placement of cells within the chamber.

The present disclosure relates generally to stents, systems, and methods for gastrointestinal treatment. In some embodiments, a stent may include a tubular scaffold having a first end opposite a second end, wherein a lumen extends between the first and second ends. The tubular scaffold may include a flared section and a medial section extending from the flared section, wherein a first diameter of the flared section is greater than a second diameter of the medial section. The stent may further include a liner extending partially along a surface of the tubular scaffold, wherein the liner is spaced from an anchoring region of the flared section to promote tissue ingrowth with the flared section.