Disclosed are sulfide-based compounds which are a product of a Michael addition reaction between a sulfur-containing donor group and an unsaturated hydrocarbon moiety. The sulfide-based compounds may be used in compositions and methods for inhibiting corrosion.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

New methods of preparing bridged bi-aromatic ligands are disclosed. The methods employ direct di-ortho-lithiation of aromatic rings of bridged protected bi-aromatic diphenols. The ligands may be used to prepare transition metal compounds useful as catalysts in olefin polymerization.

New methods of preparing bridged bi-aromatic ligands are disclosed. The methods employ direct di-ortho-lithiation of aromatic rings of bridged protected bi-aromatic diphenols. The ligands may be used to prepare transition metal compounds useful as catalysts in olefin polymerization.

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V):

##STR00001##

and/or a salt thereof, wherein R.sub.1 is OH or OP(O)(OH).sub.2, and X.sub.1, X.sub.2, X.sub.3, R.sub.2, R.sub.2a, R.sub.a, R.sub.b, and R.sub.c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V):

##STR00001##

and/or a salt thereof, wherein R.sub.1 is OH or OP(O)(OH).sub.2, and X.sub.1, X.sub.2, X.sub.3, R.sub.2, R.sub.2a, R.sub.a, R.sub.b, and R.sub.c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

A compound represented by formula (I)

##STR00001## or an N-oxide compound thereof is provided with excellent control efficacies against harmful arthropods, wherein A.sup.1 represents a nitrogen atom or a CR.sup.4; R.sup.4 represents a hydrogen atom, a OR.sup.27, a NR.sup.27R.sup.28, a cyano group, a nitro group, or a halogen atom;

##STR00002##

hereinafter referred to as Het, represents Het-1, Het-2, Het-3, or Het-4:

##STR00003## wherein #.sup.1 represents the binding position of Het and T, and #.sup.2 represents the binding position of Het and

##STR00004## T represents T-1, T-2, T-3, T-4, T-5, T-6, or T-7:

##STR00005## R.sup.1 represents a C1-C10 chain hydrocarbon group having one or more halogen atoms or the like; and R.sup.2 represents a C1-C6 alkyl group optionally having one or more halogen atoms or the like.

A method of imparting to, or modifying in, a comestible product, umami taste, including the addition to a comestible product base of at least one compound of formula (I) ##STR00001##
wherein one of X.sub.1, X.sub.2, or X.sub.3 is selected from the group consisting of S, N and O and the remaining two are CH.sub.2; and A is selected from ##STR00002##
in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 R.sub.5, R.sub.6 are independently selected from the group consisting of H, methyl, ethyl, propyl, OH, OMe, OEt, COOH, COOR.sub.7, in which R.sub.7 is selected from linear or branched C.sub.1-C.sub.7 alkyl, and CONR.sub.8R.sub.9, in which R.sub.8 and R.sub.9 are independently selected from hydrogen and straight or branched C.sub.1-C.sub.4 alkyl; or any two adjacent substituents R.sub.2-R.sub.6 together form a ring of 5 or 6 members; and n is 1 or 0.

A method of imparting to, or modifying in, a comestible product, umami taste, including the addition to a comestible product base of at least one compound of formula (I) ##STR00001##
wherein one of X.sub.1, X.sub.2, or X.sub.3 is selected from the group consisting of S, N and O and the remaining two are CH.sub.2; and A is selected from ##STR00002##
in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 R.sub.5, R.sub.6 are independently selected from the group consisting of H, methyl, ethyl, propyl, OH, OMe, OEt, COOH, COOR.sub.7, in which R.sub.7 is selected from linear or branched C.sub.1-C.sub.7 alkyl, and CONR.sub.8R.sub.9, in which R.sub.8 and R.sub.9 are independently selected from hydrogen and straight or branched C.sub.1-C.sub.4 alkyl; or any two adjacent substituents R.sub.2-R.sub.6 together form a ring of 5 or 6 members; and n is 1 or 0.