Provided herein are prodrug compounds, their preparation and their uses, such as treating liver diseases or nonliver diseases via intervening in molecular pathways in the liver.

The disclosure relates generally novel sulfur containing glycerol mono-ester derivatives and methods useful for treating gram positive, gram negative, fungal and envelope viral infections in a patient.

The disclosure relates generally novel sulfur containing glycerol mono-ester derivatives and methods useful for treating gram positive, gram negative, fungal and envelope viral infections in a patient.

A radiation-sensitive resin composition includes a resin including a structural unit represented by formula (1), a radiation-sensitive acid generator, and a solvent. R.sup.1 is a hydrogen atom, a fluorine atom, or the like. R.sup.2 and R.sup.3 each independently represent a monovalent hydrocarbon group having 1 to 10 carbon atoms, or the like. R.sup.4 is a hydrogen atom, a monovalent hydrocarbon group having 1 to 10 carbon atoms, or the like. R.sup.5 and R.sup.6 each independently represent a hydrogen atom, a monovalent hydrocarbon group having 1 to 10 carbon atoms, or the like. R.sup.7 and R.sup.8 each independently represent a hydrogen atom, a monovalent hydrocarbon group having 1 to 10 carbon atoms, or the like. R.sup.9 and R.sup.10 each independently represent a monovalent organic group having 1 to 10 carbon atoms, or the like.

##STR00001##

A radiation-sensitive resin composition includes a resin including a structural unit represented by formula (1), a radiation-sensitive acid generator, and a solvent. R.sup.1 is a hydrogen atom, a fluorine atom, or the like. R.sup.2 and R.sup.3 each independently represent a monovalent hydrocarbon group having 1 to 10 carbon atoms, or the like. R.sup.4 is a hydrogen atom, a monovalent hydrocarbon group having 1 to 10 carbon atoms, or the like. R.sup.5 and R.sup.6 each independently represent a hydrogen atom, a monovalent hydrocarbon group having 1 to 10 carbon atoms, or the like. R.sup.7 and R.sup.8 each independently represent a hydrogen atom, a monovalent hydrocarbon group having 1 to 10 carbon atoms, or the like. R.sup.9 and R.sup.10 each independently represent a monovalent organic group having 1 to 10 carbon atoms, or the like.

##STR00001##

Provided herein are surfactant compounds that can be used to aid in preparation of protein samples for analysis, for example by mass spectrometry.

Provided herein are surfactant compounds that can be used to aid in preparation of protein samples for analysis, for example by mass spectrometry.

A polymer compound is provided which is changed from a water-insoluble state to a water-soluble state by irradiation with light. The polymer compound is represented by Formula (5), where A and B are a single bond or a functional group, R.sup.3, R.sup.4, and R.sup.9 are hydrogen or an alkyl group, and R.sup.6 and R.sup.7 are hydrogen, an alkyl group, or the like.

A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1):

##STR00001##

wherein R.sup.1 and R.sup.6 are each independently a hydrogen atom or a hydrocarbon group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X.sup.1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z.sup.1 and Z.sup.2 are each independently a selected divalent spacer.

A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1):

##STR00001##

wherein R.sup.1 and R.sup.6 are each independently a hydrogen atom or a hydrocarbon group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X.sup.1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z.sup.1 and Z.sup.2 are each independently a selected divalent spacer.