Provided herein is a compound of formula (I):

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wherein each R is independently selected from the group consisting of C.sub.1-8 alkyl, C.sub.1-8 heteroalkyl having 1-4 heteroatoms independently selected from N, O, and S, C.sub.3-6 cycloalkyl, 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N, O, and S, C.sub.6-10 aryl, and 5-10 membered heteroaryl having 1-4 heteroatoms independently selected from N, O, and S; each X is independently selected from OH, PAr.sub.2, P(O)Ar.sub.2, OPAr.sub.2, C.sub.3-6 cycloalkyl, 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N, O, and S or each X together form O.sub.2PNR.sub.2; Ar is C.sub.6-10aryl; and each R is independently selected from hydrogen and C.sub.1-8 alkyl. Also provided are methods of making and using the compound of formula (I).

The present disclosure relates to compounds of Formula (P) or (II-0): (Formulae (I), (II-0)), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions. ##STR00001##

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

The present invention relates to a compound of formula (I) and salts thereof,

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The present invention further relates to catalytic complexes comprising a compound of formula I and uses thereof in the stereoselective synthesis of stereocentres, in particular, all-carbon quaternary stereocentres.

Chiral spirobiindane skeleton compound and preparation method thereof is disclosed in the present invention. The spirobiindane skeleton compound of the present invention having the structure formula of I or I; the preparation method for synthesizing the spirobiindane skeleton compound of the present invention comprising the following steps: in the presence of solvent and catalysts, the structure formula compound III reacted through intramolecular Friedel-Crafts reaction to obtain the compound of formula I; the catalyst is a Browsteric acidor Lewis acid. The preparation method of chiral fused spirobiindane skeleton compound of the present invention does not need to adopt chiral starting materials or chiral resolving agents, does not require chiral resolving steps, is simple in method, is simple in post-treatment, and is economic and environment friendly. High product yield, high product optical purity and chemical purity. The catalyst for the asymmetric reaction is obtained from the chiral spirobiindane skeleton ligand of the present invention, under the catalytic reagent of transition metal, the catalyzed hydrogenation reaction can arrive at a remarkable catalytic effect with a product yield of >99%, and a product ee value of up to >99%.

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Provided herein are cyclopropene phosphoramidites, which can be coupled to oligonucleotides to form cyclopropene-functionalized oligonucleotides. Also provided herein are methods of preparing cyclopropene phosphoramidites. Further provided herein are methods of functionalizing oligonucleotides by reaction with tetrazines, providing oligonucleotide cycloadduct products.

The present invention relates to chiral phosphoramidimidates, their salts and metal complexes as well as derivatives thereof and their use as catalysts.

The present invention provides a non-aqueous electrolytic solution comprising a phosphinoamine-based compound represented by formula (1) below and a lithium ion secondary battery comprising the non-aqueous electrolytic solution. By adding the phosphinoamine-based compound to the non-aqueous electrolytic solution, oxidative degradation in the non-aqueous electrolytic solution is suppressed, and thus gas generation is suppressed. ##STR00001##

The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

The present invention provides a non-aqueous electrolytic solution comprising a phosphinoamine-based compound represented by formula (1) below and a lithium ion secondary battery comprising the non-aqueous electrolytic solution. By adding the phosphinoamine-based compound to the non-aqueous electrolytic solution, oxidative degradation in the non-aqueous electrolytic solution is suppressed, and thus gas generation is suppressed.

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