A compound having a chemical formula according to Formula (I) is disclosed where one of Z.sub.1, Z.sub.2 and Z.sub.3 is and one of the Z.sub.1, Z.sub.2, and Z.sub.3 that is bonded to a carbon atom that is adjacent to the carbon atom bonded to is P(AR.sub.1)(AR.sub.2). Metal-based catalyst and pre-catalysts, such as nickel-based catalysts and precatalysts, where the metal is complexed to the compound are also disclosed. Methods of forming C(sp2)-N bonds are also disclosed.

Provided herein are inhibitors of TNF?, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the TNF? inhibitory compounds for the treatment of diseases or disorders.

The present application relates to the field of pharmaceutical chemistry, relates to an SOS1 inhibitor containing phosphorus, i.e., a compound of formula (I) and a preparation method therefor, and a pharmaceutical composition containing the compound, and relates to use thereof in the preparation of a drug for treating a disease and/or disorder related to SOS1 or regulated by SOS1.

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A compound of Formula (II): for use in the prevention or treatment of a bacterial infection.

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Provided herein are compounds of Formula (I-A), Formula (I-B), Formula (II-A), Formula (II-B), pharmaceutically acceptable salts thereof, and compositions thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, R.sub.14, A, B, E, W, X, and n are defined herein. The disclosed compounds are useful for treating various diseases, including depression and associated conditions.

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Provided herein are cyclic phosphorus-containing prodrug compounds, their preparation and their uses, such as treating diseases via modulating molecular targets in the liver.

A heterocyclic compound and an organic light-emitting device, the heterocyclic compound being represented by Formula 1:

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Provided herein are cyclic phosphorus-containing prodrug compounds, their preparation and their uses, such as treating diseases via modulating molecular targets in the liver.

A phosphorus-containing compound and an organic electroluminescence device including the same, the phosphorus-containing compound being represented by the following Formula 1:

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Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds.