Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described as well as for providing for other treatments. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance of cellulite. Treatments can include cooling a surface of a patient's skin and detecting at least one freeze event in the cooled skin. The treatment system can continue cooling the patient's skin after the freeze event(s) are detected so to maintain at least a partially frozen state of the tissue for a period of time.

A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.

Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

In one example embodiment, a system for stimulating tissue with the application of temperature-regulated fluid and negative pressure comprises a negative-pressure source adapted to provide negative pressure to a dressing. The system may further comprise a thermoelectric module thermally coupled to a first heat exchange chamber and a second heat exchange chamber and adapted to transfer heat between said heat exchange chambers. The thermoelectric module can be further adapted to maintain a temperature-regulated fluid fluidly coupled to the first heat exchange chamber and the dressing within a predetermined temperature range by adding heat to and extracting heat from the temperature-regulated fluid as it passes through the first heat exchange chamber.

A dual modality system includes a chassis having a receptacle and means to couple the chassis to a desired treatment area of a user's body; a durable energy subsystem coupled to the chassis, arranged and configured to deliver energy to the desired treatment area of a user's body; and a replaceable thermal subsystem arranged and configured for removable placement in the receptacle of the chassis, arranged and configured to deliver thermal energy.

A dual modality system includes a flexible chassis including a durable energy subsystem and a replaceable thermal subsystem. The durable energy subsystem has a plurality of energy emitters disposed in an emission region of the chassis having a length and a width, wherein the emission region length and emission region width are both substantially greater than an emission region depth. The replaceable thermal subsystem has a thermal source affixed to flexible web having an adhesive surface and at least one structure arranged and configured to couple the thermal subsystem to a chassis comprising a durable energy subsystem in a configuration wherein the thermal source is substantially superposed over the emission region of the chassis.

A stationary massage device, system and corresponding methods are used for self-administrated or assisted soft tissue strain release (including trigger point therapy, strain-and-counterstrain therapy and neuromuscular release). The massage device comprises a body, wherein the body may include branches, each having flat surfaces, edges, ridges or corners. The surfaces, edges and ridges may be pushed along the myofilament direction of the soft tissues to produce pressing, rubbing, stretching and pulling actions on the soft tissues as stripping massages. The system can be configured to form different geometric shapes, and made of different materials of different firmness. The system can be further configured to perform unheated, or heated massages; and cooling treatments. In addition to being used alone, the system can be mounted on a piece of wall, a standing frame, furniture or a garment.

Surface treatment devices having a flexible, fluid impermeable enclosure made of a synthetic amorphous silica; and a polydimethlysiloxane fluid contained in the enclosure. The synthetic amorphous silica may be a liquid silicone rubber, for example, s CHT True Skin liquid silicone rubber. The polydimethlysiloxane fluid may be a CHT QM Diluent. The treatment device may be used for heating or cooling a surface, for example, the surface of the human body. The liquid silicone rubber may be a CHT True Skin 10 liquid silicone rubber, and the CHT QM Diluent may be a low viscosity CHT QM Diluent, for example, a CHT QM Diluent having a viscosity of at least 50 centipoise (cps), or at least 1,000 cps. Methods for treating a surface and methods for fabricating a surface treating device are also provided.

A tissue treatment system includes an applicator connected with a base unit. The applicator includes a light source to generate light energy. A light guide directs the light energy to biological tissue and is configured to contact biological tissue. A thermoelectric cooler has a cold side and a hot side, with the cold side being associated with the light guide. A hot side plate is mounted to the hot side of the thermoelectric cooler. A first fluid passage is between the reservoir and the hot side plate to deliver cooling fluid over the hot side plate to chill the cold side of the thermoelectric cooler and cool the light guide and biological tissue. A second fluid passage is associated with the light source to direct cooling fluid to the light source prior to being returned to the reservoir. The first and second fluid passages define a single cooling fluid circulation loop.

A system for treating a subject can include an adjustable vacuum applicator configured to receive the subject's tissue by applying a vacuum. The vacuum applicator can have an cavity adjustment mechanism with different modes for widening and narrowing a tissue-receiving cavity to adjust the thermal contact between the vacuum applicator and the subject's tissue within the applicator. Sidewalls of the vacuum applicator can be moved to positive draft angle positions to help draw tissue deeper into the tissue-receiving cavity.