This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen container configured to contain a first cryogen having a first temperature and a nozzle configured to spray a first modified cryogen to the target region, the first modified cryogen having a second temperature higher than the first temperature. The device can also include a cryogen temperature regulator configured to receive the first cryogen and output the first modified cryogen to the nozzle, the cryogen temperature regulator disposed closer to the nozzle than the cryogen container. The cryogen temperature regulator can include a holder tube, a porous structure disposed inside a holder tube and a heater disposed around the holder tube and heating the holder tube so as to increase the first temperature to the second temperature while the first cryogen passes through the porous structure.

This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen transfer unit configured to receive a first cryogen from an external cryogen reservoir, the first cryogen including i) a first amount of a liquid phase cryogen and ii) at least one of a first solid phase cryogen and a first gas phase cryogen. The device can also include a nozzle configured to spray a first modified cryogen to the target region. The device can further include a cryogen liquefier disposed between the cryogen container and the nozzle and configured to cool the first cryogen received from the cryogen transfer unit and output the first modified cryogen to the nozzle, the first modified cryogen including at least a second amount of the liquid phase cryogen more than the first amount of the liquid phase cryogen.

Embodiments include methods and systems for treating joint pain associated with a nerve. A needle of a cryogenic system may be inserted beneath a skin surface. The needle may include an electrically conducting structure at least partially surrounded by an electrical insulator for conducting electrical energy. The needle may include an outer lumen and an inner lumen extending distally within the outer lumen, the inner lumen include a distal opening open to the outer lumen. The needle may be positioned at a desired location in proximity to the nerve, and a cooling therapy including cooling cycles and thawing periods may be performed to cool tissue at the desired location. The cooling therapy may sufficiently reduce the joint pain.

Embodiments include methods and systems for treating back pain associated with a nerve. A needle of a cryogenic system may be inserted beneath a skin surface. The needle may include an electrically conducting structure at least partially surrounded by an electrical insulator for conducting electrical energy. The needle may include an outer lumen and an inner lumen extending distally within the outer lumen, the inner lumen include a distal opening open to the outer lumen. The needle may be positioned at a desired location in proximity to the nerve, and a cooling therapy including cooling cycles and thawing periods may be performed to cool tissue at the desired location. The cooling therapy may sufficiently reduce the back pain.

Endotracheal devices, systems, and methods of using the same for transpulmonary thermal transfer to, e.g., induce transpulmonary hypothermia and/or warming. The endotracheal devices may include first and second lumens extending through the endotracheal device along with insulation located in an interior of the tube of the endotracheal device to limit thermal energy transfer between fluids in the first and second lumens.

Described herein are forehead-mounted temperature regulation apparatuses and methods of using them. These apparatuses may be used for improving sleep. Also described herein are methods of improving sleep using these apparatuses.

A self-contained portable air distribution system for cooling an individual by the movement of intake and exhaust air flow streams over an individual. The system includes a portable rechargeable battery operated fan that produces both an inlet intake and outlet exhaust air flow streams that provides a cooling effect by evaporating body moisture as it passes over the body.

Methods are provided for reducing body fat, volume of fat pads, and/or lipoma(s) in a subject. The methods as provided herein may include injecting a fat-sculpting liquid into a treatment region of the subject, wherein the fat-sculpting liquid has a temperature of 25 C. to 10 C. when injected and is substantially free of frozen particulates. The methods for reducing body fat in a subject may further include injecting a fat-sculpting liquid comprising saline and benzyl alcohol into a treatment region of the subject, wherein the fat-sculpting liquid has a temperature of 15 C. to 5 C. when injected and is substantially free of frozen particulates.

A body cooling system including a housing having a top portion, side portions, and a bottom portion. The top portion and the bottom portion include at least one opening. Additionally, the body cooling system includes at least one mesh layer and an absorbent layer at least partially surrounded by the mesh layer.

A non-user assisted, portable, entirely self-managed capable hypothermia device to eliminate hair loss caused by the side effects of certain chemotherapy treatments or to reduce the metabolic rate of ischemic tissue along with the severity of swelling is disclosed. The device consists of a conformal cap system, a thermally conductive liquid located between the body part to be cooled and the cap system, thermal transfer fluids, phase change materials, thermally insulated cooler, physical measuring devices, mechanical and electrical components, a smart user interface device, a battery, and an uninterruptible power controller.