The present is directed to improved systems, methods, and devices for providing skin cooling treatment. The skin cooling treatment system can include a mechanical arm and a cryospray applicator coupled to a distal end of the mechanical arm. The skin cooling treatment system can include a processor that can receive imagery of a portion of skin of a patient for receiving a skin cooling treatment and automatically identify boundaries from the received imagery to designate portions of the skin of the patient for receiving the skin cooling treatment. The processor can determine an instantaneous treatment footprint and can generate a treatment path based on the treatment footprint. The processor can control the cryospray applicator to deliver the skin cooling treatment to the skin according to the treatment path.

Embodiments include a cryogenic device for alleviating pain by cryogenically treating a nerve, the cryogenic device including a handpiece; a needle coupled to a distal end of the handpiece, the needle including a needle lumen, the needle being configured for insertion into a skin of a patient along an insertion axis at a site laterally displaced from a treatment zone proximate to the nerve. The needle is configured to resiliently bend after insertion away from the insertion axis, such that at least a portion of the needle is adapted to traverse a skin layer laterally toward the treatment zone. The device includes a cooling fluid supply tube extending distally into the needle lumen; and a cooling fluid source, wherein the cooling fluid source is coupled to the cooling fluid supply tube to direct cooling fluid into the needle lumen.

Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element may support a microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins. Because of the ability to pressurize and regulate pressure within the reaction compartment, and to individually heat each slide, each slide and a liquid solution or reagent thereon can be heated to temperatures that could not be obtained without the enclosed pressurized environment of the reaction compartment. A reagent dispensing strip having a plurality of reconfigurable reagent modules may also be used.

Embodiments include methods and systems for treating joint pain associated with a nerve. A needle of a cryogenic system may be inserted beneath a skin surface. The needle may include an electrically conducting structure at least partially surrounded by an electrical insulator for conducting electrical energy. The needle may include an outer lumen and an inner lumen extending distally within the outer lumen, the inner lumen include a distal opening open to the outer lumen. The needle may be positioned at a desired location in proximity to the nerve, and a cooling therapy including cooling cycles and thawing periods may be performed to cool tissue at the desired location. The cooling therapy may sufficiently reduce the joint pain.

A thermal pad is adapted to be placed in physical contact with a patient and to receive temperature controlled fluid from a thermal control unit. The temperature controlled fluid circulates through the thermal pad and controls the patient's temperature. The thermal pad includes first and second sheets that are sealed together about their periphery to define a fluid chamber there between. A fluid inlet and fluid outlet are fluidly coupled to the fluid chamber. In some embodiments, a filter sheet is sandwiched between the first and second sheets and arranged such that fluid entering the fluid inlet must pass through the filter sheet before exiting out of the fluid outlet. A plurality of bonds may be included that seal the first and second sheets together at a plurality of locations. In some embodiments, a non-sheet filter is positioned within the fluid chamber and filters the circulating fluid.

Methods of producing anesthesia or analgesia at an ocular tissue site are provided. Aspects of the methods include contacting the ocular tissue site with a cooling element having a temperature ranging from 0 to 30 C., such as 5 to 20 C. for an application time of 30 seconds or less so as to produce anesthesia or analgesia at the target tissue site. Also provided are devices that find use in practicing the methods.

The present disclosure relates to devices and methods for increasing the probability of a successful organ donation by decreasing organs' warm ischemia time. Furthermore, the present disclosure relates to increasing the pool of eligible donors, including donors who had prior chest surgeries or prior abdominal surgeries. The present disclosure provides a catheter extending through a cannula, wherein the cannula delivers cold perfusion fluid and the catheter blocks the aorta, forcing the cold perfusion fluid to pass to organs in the donor's abdomen. The present disclosure further provides for advancing the catheter from a retracted position to an extended position, and creating a watertight seal at the cannula to prevent backflow of cold perfusion fluid.

A personal portable cooling system and method which includes a device which rapidly cools the joints, extremities, chest, or head of a given patient and a coolant, such as a can of compressed gas/liquid is disclosed.

The invention relates to a portable cooling device for humans and/or animals, in particular a vest, a jacket, a cape, a coat or a blanket, characterized in that the portable cooling device (10) comprises at least two water atomizers, which are connected thereto, together with the reservoirs (2.2, 5) and at least two fans (2.1, 6), in that the portable cooling device (10) has a fixing device so that, when in use, a free ventilation and cooling region (11, 12) is formed between the portable cooling device (10) and the surface to be cooled (13, 14) of the human and/or animal, and in that the fans (2.1, 6) and the water atomizers together with the reservoirs (2.2, 5) for ventilating and cooling said ventilation and cooling region (11, 12) are arranged next to one another.

A dynamic support apparatus. The dynamic support apparatus includes a cushion, at least one actuator wherein the at least one actuator defines an interior volume and wherein the interior volume may be configured to be at least partially filled with a fluid, and a support disposed in the interior volume wherein the support configured to support an occupant when the interior volume is not filled with the fluid such that the support is sufficient to support the occupant.