The personal cooling misting system disclosed provides for a wearable fluid reservoir to contain a volume of misting fluid, and an electrically operated pump proximate to the reservoir to pump the misting fluid from the reservoir to a misting head. The misting head facilitates atomizing the misting fluid. The system further provides for feed tubing to direct the misting fluid from the reservoir to the pump, and distributive tubing to direct the misting fluid from the pump to the misting head. The system also includes a pump control to control at least one of a pressure and a flow rate of the misting fluid through at least one of the feed tubing and distributive tubing, and the system includes a programmable circuit board to facilitate system control via the pump control, as well as directing to the pump control a misting distribution pattern for at least one of a consistent or intermittent misting pattern.

A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.

Compositions and formulations having one or more anti-freeze proteins for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Embodiments of the technology are further directed to methods, compositions having one or more anti-freeze proteins and devices that protect non-targeted cells from freeze damage during dermatological and related aesthetic procedures requiring sustained exposure to cold temperatures. Further embodiments of the technology include systems for enhancing sustained and/or replenishing release of a freezing point depressant having one or more anti-freeze proteins to a treatment site prior to and during cooling applications.

A sleeve kit comprising a container sleeve and a sleeve cap which may be engaged with the container sleeve to form a sleeve assembly that envelopes a slush container, the sleeve kit including an attachment system to allow the sleeve cap to be engaged with the container sleeve to form the sleeve assembly and then become disengaged so that the slush container may be removed from the container sleeve. The attachment system may be a single-use attachment system to allow the sleeve cap to be engaged with the container sleeve to form the sleeve assembly. The container sleeve may have a set of at least one vent which allows air to move from an open top end of the container sleeve to a space between a bottom of an inserted slush container and a bottom of the container sleeve to facilitate removal of the slush container from the container sleeve.

A hand-held or wearable device for cooling tissue of an eye of a patient is disclosed. In one aspect, the device includes a reservoir having fluid therein and a support connected to the reservoir and configured to be positioned on a face of the patient. The device also includes a nozzle positioned proximate to the support and fluidically connected to the reservoir, the nozzle configured to pass the fluid from the reservoir onto a surface of the eye. The device further includes a cooling element configured to cool the fluid from the reservoir such that it exits the nozzle at a temperature of between 100 C. and 15 C. The device further includes an ultrasonic vibrator positioned near the nozzle and configured to generate mist from at least part of the fluid.

Delivering cold slurry to internal tissues can be used in therapies for treating a variety or medical diseases and conditions. For example, cold slurry can activate brown adipose tissue to treat obesity. Cold slurry can be delivered to tissue injured by trauma or disease to reduce inflammation, which in turn reduces pain and leads to quicker recovery. Cold slurry therapy can also be used to treat muscular and neurological disorders as well as to manage pain. The cooling effect of cold slurry delivered at or near a nerve reduces innervation that nerve, which in turn reduces spasms or pain. The cooling effect can also cause tissue to undergo the cell death. Advantageously, cold slurry therapies can be used to reduce or remove tissue, for example, to treat fibroadenomas or scar tissue.

Peritoneal heat exchange provides the benefit of extremely rapid cooling of the patient's target organs such as the heart and brain as well as facilitating global patient body temperature reduction to therapeutically effective temperatures. The heat exchange medium of the present invention is a chilled gaseous fluid suspension of frozen ice particles.

An organ can be cooled to minimize ischemic tissue damage from a vascular occlusion by a thrombus or dissection. A catheter including a thermal member can be used to introduce cold fluid downstream from an arterial occlusion to cool tissue affected by the occlusion. This is particularly useful to minimize neurologic damage from a thrombotic stroke.

The present invention provides improved devices for removing energy and fluid from body fluid containing spaces and surfaces of a mammal, the devices including isolated air and water delivery systems configured to simultaneously deliver streams of dry air and liquid water to the nostrils of a patient, without allowing the streams to come into contact with one-another until it enters the patient's nostrils.

A control unit system. The system includes a control unit which includes a control unit charging interface, at least one magnet located proximate to the control unit charging interface, at least one actuator, a detachable manifold including at least one magnet, fluidly coupled to the at least one actuator, a pump connected to the at least one actuator for causing actuation thereof, and a control system for controlling the pump, wherein the control system controls the pump to actuate the at least one actuator at least in response to a signal received by the control system. The system also includes a recharging device configured to receive the control unit, the recharging device including a reed switch, wherein when the magnet in the control unit is located proximate to the reed switch, the switch is activated.