We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

A heat transfer device particularly structured for application of thermal therapy from a contact surface to a human ear. A device may be passive (pre-cooled), active (thermoelectrically active), or include elements of both. A device may be structured to apply thermal treatment from a contact surface of a contact cavity only to a localized posterior area relative to the circumference of an ear. Preferably, a device provides an uninterrupted opening extending in a line-of-sight between an ear canal and the local environment. A device may include both of a contact cavity and a bulk cavity, with heat transfer media disposed in each cavity. Typically, a bulk cavity holds at least twice the media volume contained in a contact cavity. The cavities may be disposed in fluid communication, or separated by a barrier to permit only thermal communication there-between. When a barrier is present, a device may include different heat transfer media in each cavity. One or more device may be associated with various mounting structure to dispose a contact surface in contact with desired portion(s) of a head.

Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance sites with cellulite. Treatments can include cooling a surface of a patient's skin and detecting freezing in the cooled skin. The tissue can be cooled after the freeze event is detected so to maintain the frozen state of the tissue to improve the appearance of the treatment site.

A thermostatic massage pad includes: a thermostatic pad, wherein a thermostatic water pipe is arranged inside the thermostatic pad; a cooling pad, wherein a cooling water pipe is arranged inside the cooling pad; a casing, wherein a thermostatic water pump and a cooling water pump are respectively arranged inside the casing, a thermostatic water tank is arranged at a top of the thermostatic water pump, a cooling water tank is arranged at a top of the cooling water pump, a water inlet end of the thermostatic water pump is connected to a water outlet of the thermostatic water tank, and a water inlet end of the cooling water pump is connected to a water outlet of the cooling water tank; a thermoelectric cooler, wherein an end surface of the thermoelectric cooler is fixedly connected to a wall surface of the thermostatic water tank.

Methods for treating Blepharitis, Meibomian Gland Dysfunction and Dry Eye Syndrome include thermal massage, thermal debridement, and thermal expression. Particular embodiments include use of handheld devices that provide the thermal therapy to tissue by contacting a surface heated with thermal energy to a patient's tissue. Thermal energy can be continuously provided during operation. In particular embodiments, a handheld device comprises a base assembly operatively connected to a removeable thermal energy applicator. A wide range of thermal applicators may be connected to the base assembly to provide different treatments, including heat application, debridement, and expression of the treated tissue or gland.

This present disclosure provides devices, systems, and methods relating to modulating the temperature of a target tissue in a subject for various therapeutic purposes. In particular, the present disclosure provides devices, systems, and methods for the focal delivery of cytostatic hypothermia to a target tissue to treat a disease or condition in a subject (e.g., cancerous tumors).

A headpiece includes a shell, a thermoelectric cooler, a heat sink and a fan. The shell defines a concavity. The thermoelectric cooler includes a cooling surface and a warming surface. The heat sink is in thermal communication with the warming surface. The fan is in fluid communication with the heat sink.

A cold and heat cosmetic instrument, including: a casing, a jade massage piece, a heat sink, and a cooling and heating piece. The casing defines therein an opening, the jade massage piece is arranged at the opening, and the casing and the jade massage piece are sealed to form a first accommodation chamber. The heat sink and the cooling and heating piece are arranged within the first accommodation chamber. The cooling and heating piece is in contact with the heat sink and the jade massage piece, respectively. A cold and heat cosmetic mechanism includes: a wireless charging station and the cold and heat cosmetic instrument. A receiver device for electromagnetic induction charging is arranged within the first accommodation chamber. A wireless charging station defines therein a second accommodation chamber. A transmitter device for electromagnetic induction charging is accommodated in the second accommodation chamber and connected with a charging data cable.

An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.

Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about −5 degrees Celsius for a duration of about one minute or less, using a cooled surface that is at least 3 cm in width. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surface.